JAMA: CRP-directed, 7-day or 14-day antibiotic regimen for the treatment of Gram-negative mystemia

Overuse of antibiotics can lead to antibiotic resistance, and Gram-negative mystemia is a common infection that requires the use of a large number of antibioticsRecently, researchers compared the effects of C-reactive protein (CRP)-directed antibiotic therapy on patients with a clinical prognosis of 30, 60, and 90 days of continuous antibiotic therapystudy was conducted in Switzerland, with the participation of adult inpatients with Gram-negative mycoplasmaemia, and the duration of randomly treated with CRP-directed antibiotics (CRP stopped treatment after a 75% reduction from peak; n-170), fixed 7-day treatment duration (n-169) or a fixed 14-day duration of treatment (n-165)The main result of the study was the 30th day of clinical failure, defined as recurrent myoemia, localized pus complications, distant complications, clinical exacerbation or death, and the resumption of gram-negative antibiotic treatmentSecondary results included a clinical failure rate on the 90th day of follow-upout of 504 patients (average age 79, 61 per cent female), 493 (98 per cent) completed 30 days of follow-up and 448 (89 per cent) completed 90 days of follow-upThe duration of the antibiotics in the CRP group was 7 daysThe main events occurred as follows: 4 out of 164 patients in the CRP group (2.4 per cent), 11 (6.6 per cent) of 166 patients in the 7-day group, and 9 (5.5 per cent) of 163 patients in the 14-day group (CRP vs 14 days group: -3.1%; 7 days vs 14 days group: 1.1 per cent)By the 90th day, 10 (7.0%) of the 143 patients in the CRP group had clinical failures, 16 (10.6%) of 151 patients in the 7-day group had clinical failures, and 16 (10.5%) of 153 patients in the 14-day group had clinical failuresstudies showed that for adult patients with Gram-negative mycomosis, there was no significant difference in clinical efficacy of 30 days between CRP-directed antibiotic treatment and 7-day treatment regimens compared to 14-day treatment syllas