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Long-term smoking may have adverse consequences for the prognostication of tumor patients, and researchers recently compared the effects of continuous telephone counseling and drug therapy (enhanced therapy) and short-term telephone counseling and drug counseling (standard treatment) on smoking cessation rates in cancer patients.
this non-blind, randomized clinical trial was conducted at Massachusetts General Hospital/Dana Faber/Harvard Cancer Center and Sloan-Kettering Cancer Center.
Recently diagnosed breast, gastrointestinal, genitourinary, gynaecological, head and neck, lung, lymphoma, or melanoma patients with a history of smoking within nearly 30 days were randomly divided into intensive therapy (n-153) and standard treatment (n-150) groups.
group received 4 bi-weekly and 3 monthly telephone consultations, and the standard group received 4 weeks of counseling, including nicotine replacement therapy, aphedone or valenclin.
result of the study was a biochemically confirmed 7-day tobacco withdrawal rate over a six-month follow-up period, with the secondary result of treatment utilization.
303 patients, with an average age of 58.3 years, 170 women (56.1%) and 221 (78.1%) completed the trial.
six-month bio-confirmed withdrawal rate was 34.5% in the intensive treatment group (n-51), compared with 21.5% in the standard treatment group (n-29, with a difference of 13.0%; advantage ratio: 1.92).
in the intensive treatment group, the average number of consultations completed was 8.
a total of 97 participants (77.0%) and 68 standard treatment participants (59.1%) reported discontinuation of drug use (difference: 17.9%; advantage ratio: 2.31).
most common adverse events in the intensive care group and the standard treatment group were nausea (13 vs 6 cases), rash (4 vs 1 case), hiccup (4 vs 1 case), oral stimulation (4 vs 0 cases), sleep difficulties (3 vs 2 cases) and abnormal dreams (3 vs 2 cases).
study found that for newly diagnosed patients with smoking tumors, ongoing counseling and free smoking cessation drugs could help increase smoking cessation rates.
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