JAMA Netw open: How can men who have sex with men reduce HIV infection rates?

HIV disproportionately affects men who have sex with men (MSM)
.

Globally, pre-exposure prophylaxis (PrEP) is an evidence-based risk reduction measure that includes initiation of combined tenofovir disoproxil fumarate and emtricitabine before and during HIV exposure in HIV-seronegative individuals , to prevent HIV infection

HIV disproportionately affects men who have sex with men (MSM)

This study evaluated changes in HIV infection events, adherence, safety, and sexual behavior among gay men using daily preventive measures (D-PrEP) and event-driven preventive measures (ED-PrEP) in 4 cities in China

This non-randomized controlled trial was conducted in Beijing, Shenyang, Chongqing, and Shenzhen from December 11, 2018, to November 30, 2020, in HIV-seronegative gay men
.

Participants self-selected the D-PrEP or ED-PrEP regimen at baseline and could switch regimens during the 12-month study period

This non-randomized controlled trial was conducted in Beijing, Shenyang, Chongqing, and Shenzhen from December 11, 2018, to November 30, 2020, in HIV-seronegative gay men

A total of 1530 MSM were included in the analysis

Sexual behavior associated with HIV risk and syphilis incidence during follow-up in pre-exposure prophylaxis (PrEP) users and non-users

Sexual Behaviors Associated with HIV Risk and Syphilis Incidence During Follow-up of Pre-exposure Prophylaxis (PrEP) Users and Non-users Sexual Behaviors Associated with HIV Risk and Syphilis Incidence During Follow-up ofPre-exposure Prophylaxis (PrEP) Users and Non-users

Adherence increased over time among ED-PrEP users and decreased over time among D-PrEP users during the study period .

Daily PrEP users reported fewer adverse events than ED PrEP users .

Adherence increased over time among ED-PrEP users and decreased over time among D-PrEP users during the study period .
Daily PrEP users reported fewer adverse events than ED PrEP users .
Adherence increased over time among ED-PrEP users and decreased over time among D-PrEP users during the study period .
Daily PrEP users reported fewer adverse events than ED PrEP users .
Adherence increased over time among ED-PrEP users and decreased over time among D-PrEP users during the study period .
Daily PrEP users reported fewer adverse events than ED PrEP users .
Adherence increased over time in ED-PrEP users and decreased over time in D-PrEP users

The results of this study showed that both D-PrEP and ED-PrEP regimens were associated with lower HIV incidence and favorable safety profile among high-risk MSM in China

References: Wang H, Wang Z, Huang X, et al.
Association of HIV Preexposure Prophylaxis Use With HIV Incidence Among Men Who Have Sex With Men in China :A Nonrandomized Controlled Trial .
JAMA Netw Open.
2022;5(2): e2148782.
doi:10.
1001/jamanetworkopen.
2021.
48782 References: Wang H, Wang Z, Huang X, et al.
Association of HIV Preexposure Prophylaxis Use With HIV Incidence Among Men Who Have Sex With Men in China :  A Nonrandomized Controlled Trial .
  JAMA Netw Open.
2022  ;5(2):e2148782.
doi :10.
1001/jamanetworkopen.
2021.
48782Wang H, Wang Z, Huang X, et al.
Association of HIV Preexposure Prophylaxis Use With HIV Incidence Among Men Who Have Sex With Men in China :  A Nonrandomized Controlled Trial :  .
  JAMA Netw Open.
JAMA  2022;5(2):e2148782 .
doi:10.
1001/jamanetworkopen.
2021.
48782 doi:10.
1001/jamanetworkopen.
2021.
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