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JAMA Netw Open: With the addition of sodium thiosulfate to platinum-based chemotherapy drugs, will the risk of ototoxicity be lower for patients?

 Last Update: 2021-08-13
 Source: Internet
 Author: User

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Platinum chemotherapeutics are one of the most commonly used drugs for the treatment of solid tumors in children and adults.

Studies in recent years have found that platinum can persist indefinitely in the cochlea, which is related to long-term complications of the ear , such as sensorineural hearing loss, tinnitus and vestibular disease

On the other hand, sodium thiosulfate (STS) has become a promising ear protectant .

The researchers searched the Cochrane Library, PubMed, Embase, Web of Science, Scopus and other databases, and the deadline is November 7, 2020

The main outcome of the study is to compare the relative risk (rr) of the development of ototoxicity and hematopoietic events between the experimental group and the control group

Finally, 4 qualified studies were included, including 3 randomized clinical trials and 1 controlled study

In the trial sequence analysis of event-free survival rate (z=0.

The overall association of sodium thiosulfate (STS) and the prevention of ototoxicity

Sodium thiosulfate (STS) and the associated overall prevention ototoxic effects of sodium thiosulfate (STS) and prevention of ototoxic effects generally associated with sodium thiosulfate (STS) and the associated overall prevention ototoxic effects ofsodium thiosulfate ( STS) overall association with the prevention of ototoxicity

Simply put, this study found that the use of STS during platinum-based chemotherapy is associated with a reduced risk of ototoxic effects

This study found that the use of STS during platinum-based chemotherapy is associated with a reduced risk of ototoxic effects

References: Chen C, Huang C, Lin HH, Wang M, Chang C, Cheng Y.
Association of Sodium Thiosulfate With Risk of Ototoxic Effects From Platinum-Based Chemotherapy :A Systematic Review and Meta-analysis .
JAMA Netw Open.
2021; 4(8):e2118895.
doi:10.
1001/jamanetworkopen.
2021.
18895 Chen C, Huang C, Lin HH, Wang M, Chang C, Cheng Y.
Association of Sodium Thiosulfate With Risk of Ototoxic Effects From Platinum-Based Chemotherapy : A Systematic Review Meta - Analysis-and : .
JAMA the Open Netw.
.
2021;.
4 (.
8): e2118895.
DOI: 10.
1001 / jamanetworkopen.
2021.
18895 DOI: 10.
1001 / jamanetworkopen.
2021.
18895

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