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Severe traumatic brain injury (sTBI) in children
is a huge global problem .
Traumatic brain injury can lead to lifelong disability in survivors
Severe traumatic brain injury (sTBI) in children
Patrick M.
The main observation indicators of this study were ICP and CPP data before and after administration of hypertonic salt pills or mannitol
.
Statistical methods included linear mixed models and adjustment for potential confounders to compare the two treatments
The main observation indicators of this study were ICP and CPP data before and after administration of hypertonic salt pills or mannitol
There were 518 children (mean [SD] age, 7.
Correlation of 3% hypertonic saline and mannitol with changes in intracranial pressure (ICP)
High-dose HTS decreased ICP and increased CPP ( mean [SD] ICP, 1.
03 [6.
77] mm Hg; P; mean [SD] CPP, 1.
25 [12.
47] mm Hg; P) .
03 [6.
An increase in CPP was observed in the mannitol group (mean [SD] CPP, 1.
HTS was associated with greater reduction in ICP compared with mannitol HTS was associated with greater reduction in ICP compared with mannitol ( unadjusted beta, −0.
HTS was superior to mannitol at every threshold of observed ICP reduction when ICP was greater than 20 mm Hg, greater than 25 mm Hg, or greater than 30 mm Hg , HTS was superior to mannitol at every threshold of observed ICP reduction (>20 mm Hg: unadjusted beta, −2.
HTS was associated with lower ICP and higher CPP, whereas mannitol was only associated with higher CPP.
original source
Kochanek PM, Adelson PD, Rosario BL, et al.
Kochanek PM, Adelson PD, Rosario BL, et al.
Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury.
JAMA Netw Open.
2022;5(3):e220891.
doi:10.
1001/ jamanetworkopen.
2022.
0891 Kochanek PM, Adelson PD, Rosario BL, et al.
Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury.
JAMA Netw Open.
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