JAMA Neurol: The relationship between white matter hyperintensity and the pathology and progression of Parkinson's disease in the elderly

Parkinson's disease (PD) is one of the most common neurodegenerative diseases, characterized by bradykinesia, resting tremor, stiffness, and postural instability
.

Parkinson's disease is not benign because it is associated with many adverse health consequences, including disability, falls, dementia, and death

Parkinson's disease (PD) is one of the most common neurodegenerative diseases, characterized by bradykinesia, resting tremor, stiffness, and postural instability

Although Parkinson's disease is very common in the elderly, its pathological basis is still controversial

There are few longitudinal studies on the relationship between brain imaging or autopsy of cerebrovascular disease pathology and progressive Parkinson's disease in the elderly

Recently, some researchers have examined neurodegenerative diseases (including Parkinson's disease and cerebrovascular disease) to confirm whether the burden of white matter high intensity (WMH) is related to the incidence of progressive Parkinson's disease

This community-based cohort study included participants recruited from three ongoing cohorts registered in 1994, 1997, and 2004
.

Before death, participants received an average of 7.

This community-based cohort study included participants recruited from three ongoing cohorts registered in 1994, 1997, and 2004

The modified Fazekas rating scale was used to assess WMH load

The 26 items in the revised exercise part of the Unified Parkinson's Disease Rating Scale areused to evaluate Parkinson's disease every year

• Among the 516 deaths, 364 (70.
  5%) were women, and the average age of death was 90.
  2 years (6.
  4 years)
  .
  
• The higher the body mass index, the faster the progression of Parkinson's disease (estimated 0.
  024; SE 0.
  008; P=0.
  002)
  .
  
• When controlling the pathological indicators of cerebrovascular disease, the decrease of this correlation is greater than when controlling neurodegenerative diseases (Cerebrovascular disease: estimated, 0.
  019; SE, 0.
  008; P=0.
  02; neurodegenerative: estimated, 0.
  022; SE , 0.
  008; P=0.
  003), but the two are still significant
  .
  

Among the 516 deaths, 364 (70.
5%) were women, and the average age of death was 90.
2 years (6.
4 years)
.

Among the 516 deaths, 364 (70.
5%) were women, and the average age of death was 90.
2 years (6.
4 years)
.

The higher the body mass index, the faster the progression of Parkinson's disease (estimated 0.

     In this cohort study, higher levels of WMH and cerebrovascular disease pathological indexes in the brains of the elderly were associated with more rapidly progressive Parkinson's disease

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