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JAMA Sub-Journal: "Alzheimer's Disease" is about to be renamed?

 Last Update: 2021-07-27
 Source: Internet
 Author: User

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September 21, 2020 is the 27th World Alzheimer's Day, that is, "World Dementia Day".

According to data from Alzheimer's Disease International, the disease affects 50 million people worldwide, with an average of new cases of dementia appearing every 3 seconds

It is estimated that the number of patients will reach 25% of the population in 2030

The diagnosis and treatment of progressive cognitive dysfunction in young people is different from that of older adults

Diagnosis However, the most common causes of early-onset dementia in young adults and older adults are the same, including: Alzheimer's disease (AD), vascular dementia (VD), and frontotemporal dementia (FTD)

Early-onset dementia refers to dementia that occurs in adults aged 18-65 years

JAMA

Researchers systematically searched the population-based studies on the prevalence of YOD published between January 1, 1990 and March 31, 2020 in PubMed, Embase, CINAHL, and PsycInfo databases

This systematic review includes a total of 95 unique studies, of which 2,760,379 unique patients from 74 studies were also included in the 5-year-old meta-analysis

The age-standardized estimated prevalence rate increased from 1.

Therefore, the global age-standardized prevalence rate for the 30-64 age group is 119.

The overall age-standardized prevalence rate for the 30 to 64-year-old age group worldwide is 119.

Further analysis found that the prevalence rate in high-income countries (663.

In addition, YOD may also be related to factors such as genetics (such as Huntington's disease), mitochondrial diseases, inflammatory diseases, infectious diseases, poisoning (the causes of poisoning are alcohol, drug abuse, and heavy metals), adrenal leukodystrophy, metabolic disorders and other factors

In summary, the age-standardized prevalence rate of YOD is 1.

references:

Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis.

Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis.

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