JAMA Sub-Journal: Benign breast diseases are related to age, hormonal factors and family history of breast cancer!

Benign breast disease ( BBD ) is a general term for a series of heterogeneous breast diseases
.

BBD is a risk factor for breast cancer.

Benign breast disease ( BBD ) is a general term for a series of heterogeneous breast diseases

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Recently, published in JAMA Netw Open magazine, a study estimated BBD morbidity and BBD risk factors
.

Studies have found that the risk of BBD is related to hormonal factors and age, and family history of breast cancer is related to the risk of BBD .

Recently, published in JAMA Netw Open magazine, a study estimated BBD morbidity and BBD risk factors

This retrospective cohort study assessed from 2011 Nian 1 Yue 1 to 2013 Nian 3 Yue 31 breast cancer risk prediction Swedish daily mammography project ( KARMA ) of 70 877 women, while participants take part in the recruitment of a comprehensive Questionnaire
.

All participants had complete follow-up through high-quality Swedish national registry until 2015 Nian 12 Yue 31 Ri

This retrospective cohort study assessed from 2011 Nian 1 Yue 1 to 2013 Nian 3 Yue 31 breast cancer risk prediction Swedish daily mammography project ( KARMA ) of 70 877 women, while participants take part in the recruitment of a comprehensive Questionnaire

The results showed that a total of 61617 women with an average age of 53 years were included

Hormones cause the risk of benign breast diseases

Hormones cause the risk of benign breast diseases

Long-term use of oral contraceptives ( ≥8 years) and menopause to reduce the risk related to the former fibroadenoma ( HR , 0.
65 ; 95% CI , .
0.
47-0 90 ), after menopause, hormone replacement therapy and atypical epithelial hyperplasia ( EPA ; HR , 1.
81 ; 95%CI , 1.
07-3.
07 ), fibrocystic lesions ( HR , 1.
60 ; 95%CI , 1.
03-2.
48 ) and cysts ( HR , 1.
98 ; 95%CI , 1.
40-2.
81 ) are related to increased risk
.

In addition, family history of breast cancer is associated with an increased risk of BBD .

Long-term use of oral contraceptives ( ≥8 years) and menopause to reduce the risk related to the former fibroadenoma ( HR , 0.
65 ; 95% CI , .

Risk of benign breast disease caused by oral contraceptives and hormone replacement therapy

Risk of benign breast disease caused by oral contraceptives and hormone replacement therapy

Taken together, these results indicate that the risk of BBD varies with breast cancer subtypes, hormonal factors, and family history, and is affected by age
.

In the past few decades, the cause of BBD has not been thoroughly explored.
In the future, more relevant research is needed to determine the risk factors of BBD and understand the differences and associations between benign and malignant breast diseases

Taken together, these results indicate that the risk of BBD varies with breast cancer subtypes, hormonal factors, and family history, and is affected by age

Original source

Annelie Johansson, MSc, PhD1;  Athanasia E.

Annelie Johansson, MSc, PhD1;  Athanasia E.
Christakou, MSc, PhD1 ;  Adina Iftimi, MSc, PhD2 ; et al.
Characterization of Benign Breast Diseases and Association With Age, Hormonal Factors, and Family History of Breast Cancer Among Women in Sweden .
JAMA Netw Open.
2021;4(6):e2114716.
doi:10.
1001/jamanetworkopen.
2021.
14716 Athanasia E.
Christakou, MSc, PhD1 Adina Iftimi, MSc, PhD2 Characterization of Benign Breast Diseases and Association With Age, Hormonal Factors, and Family History of Breast Cancer Among Women in Sweden in this message