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    Home > Active Ingredient News > Study of Nervous System > JAMA sub-journal: Maintenance IVIG is associated with significantly less recurrence of MOG-AD disease

    JAMA sub-journal: Maintenance IVIG is associated with significantly less recurrence of MOG-AD disease

    • Last Update: 2022-05-22
    • Source: Internet
    • Author: User
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    Myelin oligodendrocyte glycoprotein (MOG) is one of the proteins constituting the myelin sheath of the central nervous system.


    Myelin oligodendrocyte glycoprotein (MOG) is one of the proteins constituting the myelin sheath of the central nervous system.


    Recent studies suggest that maintenance intravenous immunoglobulin (IVIG) may be an effective treatment for preventing recurrence of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) ; Few studies have evaluated IVIG in adult patients


    To determine the relationship between maintenance IVIG and prevention of relapse in adult patients with MOGAD, experts from the Mayo Clinic conducted a retrospective cohort study


    To determine the relationship between maintenance IVIG and prevention of relapse in adult patients with MOGAD, experts from the Mayo Clinic conducted a retrospective cohort study


    Of the 876 adult MOGAD patients initially identified, 59 (median age, 36 years; 33 women [56%]) received maintenance IVIG


    Schematic diagram of the pathogenesis of MOG-AD

    Schematic diagram of the pathogenesis of MOG-AD

    Twenty patients (34%) had at least 1 recurrence while receiving IVIG, the median (range) time to first recurrence was 1 (0.


    Twenty patients (34%) had at least 1 recurrence while receiving IVIG, the median (range) time to first recurrence was 1 (0.


    Results of this retrospective, multicenter, cohort study of adult MOGAD patients showed that maintenance IVIG was associated with a reduction in disease recurrence


    references:

    references:

    Association of Maintenance Intravenous Immunoglobulin With Prevention of Relapse in Adult Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease.


    Association of Maintenance Intravenous Immunoglobulin With Prevention of Relapse in Adult Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease.
    JAMA Neurol.
    Published online April 04, 2022.
    doi:10.
    1001/jamaneurol.
    2022.
    0489 Association of Maintenance Intravenous Immunoglobulin With Prevention of Relapse in Adult Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease.
    JAMA Neurol.
    Published online April 04, 2022.
    doi:10.
    1001/jamaneurol.
    2022.
    0489Leave

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