JAMA: Treatment Options for Patients With Chronic Pancreatitis Pain

Observational studies have shown that early surgery can reduce the progression of chronicpancreaticpain disease, and researchers recently compared the effects of early surgery vs endoscopy on patients'clinicaloutcomesESCAPE study was conducted in the Netherlands, involving 88 patients with chronicpancreatic, who had recently started using prescription opioids due to pain, 44 of whom underwent early surgery, pancreatic drainage surgery within six weeks, 44 patients with endoscopy and medical treatment, including endoscopy, including shock and surgery if necessaryThe main endpoint of the study was the Izbicki pain score, and the secondary endpoint scored pain relief, interventions, complications, hospitalizations, pancreatic function, quality of life, and mortalityThe trial was completed with an average age of 52 years forpatients, 21 (24%) females and 85 patients (97%)During the 18-month follow-up, the Izbicki pain score for patients in the early surgical group was lower than that of endoscopic patients (37 vs 49; inter-group difference: -12 points)At the end of the follow-up, 23 (58%) of the 40 patients in the early surgery group achieved full or partial pain relief, while only 16 (39%) of the 41 patients in the endoscopic inspection group were able to achieve full or partial pain reliefThe total number of interventions in the early surgical group was lower (median, 1 vs 3)Intergroup complications (27% vs 25%), mortality (0% vs0%), admission rate, pancreatic function and quality of life were not significantly different study found that early surgical treatment in patients with chronic pancreatitis pain can alleviate the progression of the disease and improve the prognosis