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Amivantamab (Rybrevant®) developed by Janssen Bio is a bispecific antibody targeting c-MET/HGFR and EGFR.
Lung cancer is the most common type of tumor, and it is also a tumor with high mortality worldwide.
Amivantamab was approved based on a multi-center, open-label, multi-cohort trial that included 81 NSCLC patients with EGFR exon 20 insertion mutations.
The details of Amivantamab and the double antibody drugs targeting c-MET/HGFR and EGFR are shown in the figure below:
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