Japan develops anti-inflammatory substances that are no less effective than steroids

Japanese researchers have developed an anti-inflammatory substance that works as well as steroidsThis peptide inhibits the activity of substances that play a central role in the inflammatory response, with few side effects and is expected to be used to treat allergies and dermatitisA substance called "NF- B" plays a central role in the inflammatory response, and steroid preparations are used primarily to suppress the substance's role, the Nikkei Business News reported recentlyAn analysis by researchers at StMary's Medical University in Japan found that a specific protein fragment plays an important role in the anti-inflammatory mechanism of steroids, which alone inhibits the activity of "NF-B"Using this protein as a reference, the researchers designed a peptide that binds to "NF-B", a special structure that can enter cellsThe researchers experimented with cultured cells, first adding inflammatory substances to the culture, and the activity of "NF-B" increased immediatelyThey then sprayed the newly developed peptides on the cell surface, and the result was that the activity of "NF-B" became normal, the same effect as steroidsAlthough steroids can effectively suppress inflammatory responses, they can lead to decreased immunity, stomach ulcers anddiseases such as diabetesSteroids also break the balance of hormones in the body, and hormones may be difficult to secrete after stopping the drugIn contrast, newly developed peptides have much fewer side effects and do not affect hormone balanceAccording to reports, the researchers plan to improve the peptide and begin animal experiments in 2007(Xinhua News Agency, without permission, is strictly prohibited to reproduce)