JBC: selenium compounds enhance the immune system against cancer

Cancers such as melanoma, prostate cancer and certain types of leukemia weaken the body by over activating the natural immune system Now researchers at the University of Copenhagen have shown that naturally occurring selenium compounds like garlic and broccoli slow down immune overreaction In the long run, this may improve cancer treatment The results of this study have been published in the Journal of biological chemistry The main purpose of the immune system is to remove abnormal substances from the body As a result, altered cells, such as precursor cells of cancer cells, are usually recognized and cleared by the immune system Unfortunately, different cancer cells contain mechanisms that block the immune system from recognizing them, allowing cancer to continue to develop Some cancer cells over express the immune stimulating molecules in liquid form, and over stimulation has a negative effect on the immune system It can be said that stimulation molecules over activate the immune system and lead to the collapse of the immune system Researchers have been interested in blocking this mechanism Now, we have shown that some selenium compounds effectively block the special immune molecules that play an important role in cancer, such as malignant melanoma, prostate cancer and some types of leukemia In this study, the researchers focused on the so-called ngk2d ligand, which has eight variants, one of which has attracted the attention of the researchers Once cancer is rampant, soluble ngk2d ligands cause serious problems Researchers continue to learn more about the mechanisms that lead to aggressive skin cancer, blood cancer and reproductive organ cancer Overexpression of immunostimulatory molecules in cancers such as malignant melanoma, prostate cancer and some types of leukemia significantly weakens the immune system If we can find a way to slow down the over stimulation, we can better treat the tumor