Jet contraception: the revolution in birth control technology

It is this unspectacular "jet pill" that has revolutionized human birth control technology(File photo), the Netherlands Oganon company and Australia's Akolux company signed an agreement to develop jet-based contraceptivesThe drug only needs a simple operation, can spray the contraceptive pill on the skin, the drug through penetration, spread into the bloodThe company wants to provide users with simpler and more convenient contraceptionMore importantly, of course, the company expects to reap the benefits of the $6.7 billion global market for contraceptivesCheng Cheng finally got married after 8years of loveCheng Cheng is a professional dancerAt the age of just five, she was away from her family for the dance she loved, and after more than a decade of near-hell training, she finally became the dance troupe's first heroineAt this time, the god of love also came to "visit" her, for many years down, in the family's "forced" under, she agreed to her boyfriend's proposalBut with marriage comes the question of how to use contraceptionBecause she knew that dance was a beautiful and short-lived career, and that her choice of contraception and medication was not the right one, and perhaps her dance career was overIn fact, it's not just Cheng Cheng, contraception is a very depressing thing for allwomenwomen need contraception for more than 30 years of their lives, experts say Therefore, contraceptive methods and drugs have become the most important concern of women, but also whether women can be comfortable, health life security Since contraception seems to have become a woman's vocation, almost all contraceptives, with the exception of condoms, have been developed for women's IUDs, subcutaneous injections, oral contraceptives, and intrauterine devices containing slow-release progesterone have become the main contraceptive methods for women In recent years, the development of subcutaneous implants and other technologies, to women to provide a long-term, effective means of contraception, but also there are some drawbacks, for example, when discontinued must be removed by a professional doctor, will cause different degrees of menstruation disorders Oral contraceptives are being used by more and more women of childbearing age because of their efficient, low side effects, good cycle regulation and improved skin condition and bleeding patterns in women However, the side effects of oral contraceptives cannot be ignored, and with the development of the release technology, scientists are constantly working to develop safer, more efficient and easy-to-use contraceptives Recent foreign research has succeeded in a jet-based contraceptive pill, in the words of experts, a "revolution in birth control technology" New technology help
on February 28th Acrux, an Australian biotech company, announced that The Netherlands' Organon pharmaceutical company had obtained a company license to use Acrux's transdermal technology to produce new contraceptives Using the drug, which uses the transdermal release technology, the company hopes to eliminate side effects of oral contraceptives such as vomiting, diarrhea, absorption fluctuations and metabolic disorders If successful, the company is expected to generate significant revenue in the global market for contraceptives, which have a market capitalisation of $6.7 billion (about 5.1 billion euros) The new drug is easy to use: just use a hand-holding dressing machine and spray fast-drying, easy-to-use drugs on the skin The active ingredients of the drug include ethanol carriers, as well as skin penetration enhancers Within 1 minute of spraying, the volatile components quickly disappear, while the contraceptive pill and skin penetration enhancer components are absorbed, forming a storage agent inside the outer skin, and after 24 hours, the pill spreads into the bloodstream Once a day with the spray, a steady dose of the pill is released into the bloodstream The treatment process for the new product is similar to that of traditional contraceptive products, where by using the drug daily before the contraceptive is determined By design, compounds must be absorbed into the outer skin within 1 minute of squirting out, otherwise the drugs on the skin will be lost due to the interference of clothing, contraception will fail But clinical studies already done by Acrux show that swimming or showering does not affect the effectiveness of contraception within 30 minutes of taking the drug The spray itself can be used anywhere in the skin, whereas traditional drugs in the past were usually used on the skin of the inner arm Acrux CEO Richard Treagus said the spray is a convenient and direct way to dry quickly, with no trace after use and no irritation to the skin Hormones can go directly into the bloodstream, avoiding absorption of the digestive system Each dressing usually provides a one-month drug, but the choice of the dressing is to use a disposable dressing, change it once a month, or a reusable dressinger with a separate tube, and No Dr Treagus said there were indications that Ocanong might choose a hybrid dressing For dressing products, there should be children's protection, locking, dosage and recording functions The cost of the jet-based pill is likely to be similar to that of oral contraceptives currently on the market, and the company expects the new product to be valid for two years In good faith
agreed by the two companies, Acrux will be responsible for the selection of contraceptives, and Oganon will be responsible for the clinical trial, approval, production and marketing of the drug, and assume all the funds for these processes For each compound that Ocano selected for development, Acrux will receive $12 million to $16 million for milestone payments during the research and development process, as well as a split from each product that Oganon sells globally In 2006, the global market value of hormonal contraceptive products was approximately $6.7 billion The use of broad-based, safe and attractive contraceptive products is considered to be one of the most important issues in contraception In this way, women can choose the most appropriate way to meet their needs and lifestyle "Oganon's products are market-oriented, but we want to target the U.S and European markets as our main targets," Treagus said In the United States alone, the market value of legally sold contraceptives is more than $400 million a year But it's a good sign for our new product We believe that the distinctive contraceptive pill, coupled with advanced transdermal products, will certainly achieve a good harvest "
Acrux has independently developed a contraceptive spray based on acetone acetone (progesterone) and successfully completed Phase I clinical studies last year Ocanohashas has also selected the first contraceptive compound and will begin spraying work on the drug immediately The company expects the first contraceptive spray to be available within four to five years, and while Acrux's acetone progesterone contraceptive spray is developed first, Treagus said Oganon's products could be available before Acrux's products Acrux hopes to further strengthen its partnership with Ocano, which can be applied to Other Therapeutic drugs such as fertility, gynecology and anesthesia Link transdermal release drug than conventional drug type has many advantages: can be stable through the skin penetration of the drug into the human body, maintain a constant concentration of blood (intravenous injection although can also obtain a stable concentration of blood, but the injection site often causepain, etc.
); Another advantage of transdermal administration is the convenience of drug use, especially some as long as 1 week 1 time medication Nausea, vomiting patients difficult to oral administration, gastrointestinal stimulation or easy to degrade drugs in the gastrointestinal tract may be a wise choice, the use of electricity, ultrasound, heat and other active relief can also achieve better release effect, but inevitably temporary damage to the skin and potential skin immune problems At present, the world transdermal drug system is growing at an annual rate of 15% Due to this low market base, the annual growth rate exceeds that of the oral and inhalation release system sedative systems market The market size of the transdermal drug system was $12.7 billion in 2005 and is projected to reach $21.5 billion in sales by 2010 and $31.5 billion in 2015 Australia's Acroix Company's transdermal technology platform consists of three parts: (1) MDTS technology technology made of sprayer (2 ;(022 patent expires), easy to use, accurate content, flexible dose regulation; (Zizi) (reproduced from the Journal of Medicine and Economics)