JGG Saccharomyces cerevisiae responds to changes in environmental conditions through transcriptional memory

On October 30, 2021, the Journal of Genetics and Genomics published an online research paper entitled "Transcriptional memory of different types of genes is generally maintained under various environmental conditions in Saccharomyces cerevisiae" by Professor Du Haining's team from the School of Life Sciences, Wuhan University
.

This paper reports the universal phenomenon of transcriptional memory of different types of genes in Saccharomyces cerevisiae under various environmental conditions
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https://doi.
org/10.
1016/j.
jgg.
2021.
10.
007 When eukaryotes are stimulated by certain environmental conditions, some genes (such as immune response-related genes) can be activated by a rapid response when they are stimulated by the second time.
This phenomenon is called transcriptional memory
.

Transcriptional memory is of great significance for the body to adapt to environmental changes faster, and it is closely related to the occurrence of diseases (such as diabetes) and innate immunity
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However, the research on whether transcriptional memory phenomenon exists in different genes and how long exist is relatively lacking
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The study used Saccharomyces cerevisiae to explore the transcriptional memory of different genes and found that: 1.
The transcriptional memory of the GAL gene induced by galactose after four cycles of "inhibition-reactivation" short-term inhibition still exists, and after a low temperature silence for up to a week After long-term inhibition, it can also be quickly activated; 2.
After transcriptional memory occurs, yeast cells are more sensitive to galactose-induced GAL gene expression; 3.
Lack of glucose or nitrogen source nutrition can induce cell autophagy, autophagy Related genes also have transcriptional memory, and the transcription factor Msn2/4 is necessary for the transcriptional memory of autophagy genes induced by glucose deficiency, but does not affect the transcriptional memory under the condition of nitrogen deficiency; 4.
Metabolism-related genes, heat shock Genes also have transcriptional memory characteristics
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In summary, the study revealed that under different environmental stimuli, S.
cerevisiae autophagy genes, metabolism-related genes, and heat shock genes can all respond to environmental changes through transcriptional memory
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This result suggests that in higher eukaryotes, perhaps transcriptional memory is also a widespread gene expression regulation mechanism, which opens up new ideas for the study of gene expression regulation mechanisms in higher eukaryotes
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The phenomenon of transcription and memory of different types of genes in different environments Ruxin Wang, a master's student in the School of Life Sciences, Wuhan University, is the first author of the paper, and Professor Du Haining is the corresponding author
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This work was funded by the National Key Research and Development Program, the National Natural Science Foundation of China and other projects
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 Cite this article: Ru-Xin Wang, Yu-Min Li, Runfa Chen, Hai-Ning Du.
(2021).
Transcriptional memory of different types of genes is generally maintained under various environmental conditions in Saccharomyces cerevisiae.
Journal of Genetics and Genomics.
DOI : 10.
1016/j.
jgg.
2021.
10.
007.
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