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JNCCN: Survival of melanoma patients with positive sentinel lymph node (SN) and extranodal extension of the SN envelope (ENE)

 Last Update: 2021-07-30
 Source: Internet
 Author: User

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In patients with melanoma, positive sentinel lymph node (SN) is an important indicator for identifying a high risk of recurrence, and these patients should be candidates for adjuvant therapy
.

15% to 20% of melanoma patients can find lymph node metastasis through lymph node biopsy (SNB)

In patients with melanoma, positive sentinel lymph node (SN) is an important indicator for identifying a high risk of recurrence, and these patients should be candidates for adjuvant therapy

The study included 1047 patients, including 148 (14.
1%) patients with ENE and 899 (85.
9%) patients without ENE
.

The median follow-up time for SNs-positive patients with and without ENE was 81 months and 69 months, respectively

The study included 1047 patients, including 148 (14.

The 5-year disease-free survival (DFS) rates of SNs-positive patients with and without ENE were 54.
0% (95% CI, 45.
7%-263.
8%) and 64.
0% (95% CI, 60.
5%-267.
7%), respectively , And the 10-year DFS rates were 33.
7% (95% CI, 25.
4%-244.
8%) and 45.
2% (95% CI, 40.
9%-249.
9%)
.

There was no significant difference in the rough cumulative incidence (CCIs) of local and regional recurrence between the two groups

The 5-year disease-free survival (DFS) rates of SNs-positive patients with and without ENE were 54.

DFS

In multivariate analysis, only age (OR, 1.
80; 95% CI, 1.
272-2.
56; P<0.
001), size of SN main metastases (OR, 9.
99; 95% CI, 5.
552-17.
96; P<0.
001), after CLND The number of non-SNs positive (p=0.
001) is related to ENE
.

ENE related factors

Multivariate Cox regression model analysis found that ENE, age, ulcers, the size of SN main metastases, and the number of non-SN metastases were prognostic factors for OS and DFS (all p<0.
001)
.

OS and DFS related factors

In summary, studies have shown that ENE is a prognostic factor for patients with sentinel lymph node (SN) positive melanoma
.

This indicator is helpful for clinical screening of patients who need adjuvant chemotherapy

In summary, studies have shown that ENE is a prognostic factor for patients with sentinel lymph node (SN) positive melanoma

Original source:

Maurichi A, Barretta F, Patuzzo R, et al.

Maurichi A, Barretta F, Patuzzo R, et al.
Survival in Patients With Sentinel Node-Positive Melanoma With Extranodal Extension.
J Natl Compr Canc Netw.
2021 Jul 26:jnccn20357.
doi: 10.
6004/jnccn.
2020.
7693.
Epub ahead of print.
PMID: 34311443.
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