Jneurosci: how Alzheimer's disease is transmitted through the brain

February 12, 2020 / Biovalley BIOON / -- according to a study of mouse neurons published on jneurosci, tau can spread rapidly among neurons, but will not cause immediate damage Intervention during the initial accumulation of tau protein may prevent the development of Alzheimer's disease One sign of Alzheimer's disease is the accumulation of tau protein in neurons, which leads to the death of neurons The tau protein of the lesion was not folded correctly, which resulted in the accumulation of tau protein Researchers didn't know the time scale of the process, or how misfolded taus spread to other cells Photo source: https://cn.bing.com hallinan et al Introduced diseased tau into cultured mouse neurons Within a few days, the activated tau diffused to other neurons and began to misfold and accumulate Despite the accumulation of tau protein, the transmitting and receiving neurons are healthy and able to send electronic information These results show that the accumulation of tau is harmless, and its harm comes from the process of killing neurons caused by accumulation Reference: Katrin deinhardt et al Tau misfolding efficient projections between individual intake hippocamporal neurons, jneurosci (2019) Doi: 10.1523/jneurosci.1590-19.2019