JNNP: CAIDE dementia risk score is associated with severity and progression of cerebral small vessel disease in healthy middle-aged adults

Cerebral small vessel disease (SVD) is considered a major factor in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD)

Vascular Hypertension Prevention Although it is generally protective against infection and injury, a persistent inflammatory response can be detrimental to surrounding tissues

Managing Dementia (CAIDE) Score Cholesterol This paper aimed to investigate the relationship between midlife CAIDE score and SVD and inflammation in a cross-sectional manner

Nineteen cognitively healthy middle-aged participants, aged 40-59 years, were recruited

The CAIDE score was composed of weights for age, sex, education, systolic blood pressure, BMI, total cholesterol, physical activity, and APOE4 genotype (all variables measured at baseline)

WMH was scored visually on fluid-attenuated inversion recovery (FLAIR) MRI according to the Fazekas scale for calculating the SVD composite score

Higher CAIDE risk scores were cross-sectionally associated with greater SVD burden (WMH, CMB, lacunar, EPV, SVD composite score) and systemic inflammation (CRP, fibrinogen)

Higher CAIDE risk scores were cross-sectionally associated with greater SVD burden (WMH, CMB, lacunar, EPV, SVD composite score) and systemic inflammation (CRP, fibrinogen)

Link: Dementia risk prediction after 20 years (CAIDE score) in middle-aged people

Dementia risk prediction after 20 years (CAIDE score) in middle-aged adults LowA ,Prats-SedanoMA ,StefaniakJD LowA Low Prats-SedanoMA Prats-Sedano StefaniakJD Stefaniak , et al CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study Journal of Neurology, Neurosurgery & Psychiatry  Published Online First:  08 February 2022.
  Published Online First: doi:  10.
1136/jnnp-2021-327462 doi:

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