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Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS) that mainly affects the optic nerve and spinal cord
.
About 60%–80% of patients’ serum contains disease-specific aquaporin-4 antibody (AQP4 IgG), which leads to primary autoimmune astrocytosis with a characteristic recurrence process
About 60%–80% of patients’ serum contains disease-specific aquaporin-4 antibody (AQP4 IgG), which leads to primary autoimmune astrocytosis with a characteristic recurrence process
Only about 5% of AQP4 IgG seropositive NMODS are pediatric cases
.
To the rarity of the disease, long-term clinical outcome data AQP4 IgG positive serum pediatric patients rarely and require further evidence, particularly because new treatments are emerging, this is the result of a long-term study, the study is from a few A relatively large child-onset AQP4 IgG NMOSD cohort recruited by the British Neurology Center
The subject of the study was a relatively large cohort of childhood-onset AQP4 IgG NMOSD recruited from several British neurology centers
A retrospective analysis from six British optic neuromyelitis centers
.
All data are standard clinical care data of their respective centers (6 months neurological and ophthalmological follow-up, serum AQP4 IgG detection, diagnostic magnetic resonance imaging and cerebrospinal fluid-CSF)
A total of 49 children with AQP4 IgG (38.
8% were white, 34.
7% were black, 20.
4% were Asian, and 6.
1% were mixed) were enrolled.
The average age of onset of the patients was 12±4.
1 years and 87.
7% were women
.
26.
A total of 49 children with AQP4 IgG (38.
Of the 79-month median duration of disease in the cohort, 34.
Early predictors of the probability of first relapse, visual disability, EDSS score, and cognitive impairment
Early predictors of the probability of first relapse, visual disability, EDSS score and cognitive impairmentChildren under 12 years old relapse earlier than children 12-18 years old
.
Compared with people under the age of 12, blacks account for a larger proportion of people aged 12-18
In summary, age of onset, race, symptoms of onset, and resistance to acute treatment at onset can predict first relapse and long-term disability
.
The understanding of these predictors may help promote future pediatric clinical trials and guide early treatment decisions for AQP4 IgG NMOSD
.
Age of onset, race, symptoms of onset, and resistance to acute treatment at onset can predict first relapse and long-term disability
.
Age of onset, race, symptoms of onset, and resistance to acute treatment at onset can predict first relapse and long-term disability
.
CameraV ,MessinaS ,ElhaddKT CameraV Camera MessinaS Messina ElhaddKT ElhaddKT Elhadd , et al Early predictors of disability of paediatric-onset AQP4-IgG-seropositive neuromyelitis optica spectrum disorders , et al Journal of Neurology, Neurosurgery & PsychiatryPublished Online First:28 September 2021.
Published Online First: doi: 10.
1136/jnnp-2021-327206doi:Leave a message here
