JNNP: Relationship between Smoking and ALS: Mendel Random Causality Survey.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons that causes skeletal and myeloid paralysis, usually dying of neuromuscular respiratory failure within 2 to 3 years of the onset of symptoms.
incidence of ALS is 1-2 per 100,000, with a lifetime risk of about 1 in 300.
age of ALS was 58 years, and the incidence rate was slightly higher for men than for women.
up to 40 per cent of the genetics may be related to the environment, and although extensive research has been conducted on smoking, the results have been mixed and there is no clear evidence of a link between smoking and ALS.
used the results of a recently published large genome-wide association study and Mendel randomization method to assess the relationship between smoking and ALS.
The authors defined a tool for a lifetime smoking index, a continuous smoking measure of a genome-wide association study of 46,3003 people, with 126 independently associated single nucleotide polymorphisms (SNPs), with genome-wide significance, explaining the 0.31% variation.
authors also defined a "lifetime smoking" approach, a two-step system of exposure to smoking in a genome-wide association study of 1,232,091 individuals, of which 378 major genome-wide SNPs accounted for 4% of the variation.
the differences explained in both studies are consistent with genome-wide association studies, which have been used to assess the causality of smoking under other conditions.
methodology identified two genome-wide association studies that investigated lifetime smoking (n s 463 003) and former smoking (n s 1 232 091) and used it to define the tool variables for smoking.
genome-wide association study of ALS (20,806 cases; 59,804 controls) was used as a result of deficit-weighted Mendel randomization and four other Mendel randomization methods to test whether smoking was a causal relationship to ALS.
analysis is bidirectional to assess the reverse causality.
: There is no strong evidence of a causal or reverse causal relationship between smoking and ALS.
the results of Mendel's randomization using a deficit-weighted method were 0.94 (95% CI 0.74 to 1.19) and 0.59 p;
original link: Opie-Martin S, Wootton RE, Budu-Aggrey A, et Relationship al-between smoking and ALS: Mendelian randomisation of testing causality Journal of Neurology, Neurosurgery and Psygy Published Online First: 26 August 2020. doi:10.1136/jnnp-2020-323316MedSci Original Source: MedSci Original !-- Content Presentation End -- !-- To determine whether to log in.