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JNNP: The change rate of acetylcholine receptor antibody levels predicts the prognosis of myasthenia gravis

 Last Update: 2021-04-17
 Source: Internet
 Author: User

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Myasthenia gravis (MG) is an impact of their own neuromuscular junction synaptic membrane of immune diseases.

Immune diagnosis

The flowchart shows the process of determining the participants to be analyzed

However, the correlation between the clinical status of individual patients and AChR-Ab levels remains unclear.

In this study, the purpose of this article is to determine whether the newly developed rate of reduction of AChR-Ab levels (RR-AChRAb) measured before and after immunosuppressive therapy in this study reflects treatment response and predicts the prognosis of MG.

fund

The change in the absolute value of the acetylcholine receptor antibody level and the MG-ADL score between each measurement in the ELT classification

The MG-ADL score showed a gradual downward trend at all time points.

This observational study retrospectively studied the relationship between the change rate of AChR-Ab levels before and after immunosuppressive treatment in MG patients and the clinical outcome one year after treatment.

RR-AChRAb can predict the 1-year prognosis and steroid responsiveness of MG.
RR-AChRAb can predict the 1-year prognosis and steroid responsiveness of MG.
KojimaY ,UzawaA ,OzawaY KojimaY Kojima UzawaA Uzawa OzawaY Ozawa , et al bmj.
com/content/early/2021/03/25/jnnp-2020-325511" target="_blank" rel="noopener">Rate of change in acetylcholine receptor antibody levels predicts myasthenia gravis outcome Journal of Neurology, Neurosurgery & Psychiatry Published Online First: 25 March 2021.
Published Online First : doi: 10.
1136/jnnp-2020-325511 doi:

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