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Neuromyelitis optica spectrum disorders (NMOSDs) are recurrent autoimmune diseases that affect the central nervous system (CNS)
.
Common clinical symptoms of NMOSD include optic neuritis (ON), acute myelitis and sequelae syndrome
In the retina, astrocytes are mainly located in the inner axon layer of the retina, but AQP4 is highly expressed in retinal Müller cells
Primary and non-aggressive astrocytosis in NMOSD may cause retinal neurodegeneration and Müller cell-related parafoveal changes
.
Recent studies have shown that the underlying astrocytosis-related outer retinal layer (ORL) AQP4 IgG seropositive NMOSD thins, but the sample size is limited, and there are some contradictions in the exact layer where these changes occur
In this study, compared with healthy controls (HCs), patients with AQP4 IgG seropositive and MOGAD patients as disease controls were investigated whether ORL thinning occurred, especially in the fovea and macular ONL
A total of 539 NMOSD patients were recruited as part of CROCTINO
.
It also included 75 HCs (recruited from Barcelona, Isfahan, Mangalore, and Berlin) whose age and gender did not match the two cohorts
A total of 539 NMOSD patients were recruited as part of CROCTINO
Patient cohort design and exclusion criteria
All OCT images conform to the OSCAR-IB standard
.
The thickness of the retinal nerve fiber layer (pRNFL) around the capillaries is determined using a specific device protocol, centered on the optic nerve head
All OCT images conform to the OSCAR-IB standard
Comparison of the average OCT between the HC group and the AQP4 IgG and MOG IgG seropositive patient group
AQP4 IgG positive patients OPL (25.
02±2.
03 µm) ONL (61.
63±7.
04 µm)) and healthy controls (OPL: 24.
58±1.
64 µm; ONL: 63.
59±5.
78 µm), no significant thinning of OPL or ONL was observed
.
Compared with the healthy control group (20.
AQP4 IgG positive patients OPL (25.
LuA ,ZimmermannHG ,SpecoviusS LuALu ZimmermannHGZimmermann SpecoviusSSpecovius, et alJournal of Neurology, Neurosurgery & PsychiatryPublished Online First:28 October 2021.
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