echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Study of Nervous System > JPD: Parkinson's patients, small subcortical volume, or suggest gait disorder

    JPD: Parkinson's patients, small subcortical volume, or suggest gait disorder

    • Last Update: 2021-11-02
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Parkinson's disease (PD) is a neurodegenerative disease characterized by a variety of balance and gait disorders


    These obstacles, combined with impaired postural responses, lead to impaired balance and gait, falls, and poor quality of life


    The pattern and severity of balance and gait disorders differ between patients with Parkinson's disease and elderly people without neurological disorders


    However, balance and gait may be independent functions and may be controlled by different brain regions


    Although neuroimaging studies have shown that both subcortical and cortical areas are affected in Parkinson’s disease, either due to changes in volume, loss of neurotransmitters or changes in functional connections, the loss of cortical and subcortical gray matter volume is related to specific The relationship between type of balance and gait disorder is unclear


    Since gray matter loss in many cortical and subcortical areas is related to gait freezing, the relationship between brain volume and balance and gait disturbances may differ between frozen and non-freezing individuals


    In this way, Anjanibhargavi Ragothamana of Oregon Health and Science University et al.


    Specifically, they predict that the damage of balance and gait in different areas of PD patients will be related to the atrophy of different brain regions


    The study explored the relationship between ventricle size, global and regional brain volume, and 112 objective measures in the four areas of balance and gait


    They included the regional volume of the brain structure images of 96 PD and 50 control subjects


    The multiple linear regression model evaluated the relationship and interaction between the brain volume and balance/gait of PD and the control group, controlled for gender and age, and adjusted for multiple comparisons


    They found that in PD patients, smaller brainstem and subcortical gray matter volumes were related to larger swing areas, but not in healthy controls


    In PD patients, smaller brainstem and subcortical gray matter volumes are related to larger swing areas, but not in healthy controls


    In contrast, in the healthy control group, a larger ventricle volume was associated with a smaller APA, but not in PD patients


    The study showed that smaller subcortical and brainstem volume may be an indicator of standing balance dysfunction in PD patients, and enlarged ventricles may be related to the difficulty in gait initiation in healthy elderly people





    Relationship Between Brain Volumes and Objective Balance and Gait Measures in Parkinson's Disease



    Leave a message here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.