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Junjing Bio's fourth-generation EGFR inhibitor applied for clinical application

 Last Update: 2022-05-26
 Source: Internet
 Author: User

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Article source: Medical Cube Info

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On March 30, the CDE official website showed that the clinical application for WJ13404 tablets of Junjing Bio (a joint investment of Junshi Bio and Weijing Bio) was accepted by the State Food and Drug Administration

WJ13404 is a potent fourth-generation EGFR inhibitor with preclinical data showing that the drug molecule inhibits acquired EGFR insensitive to third-generation EGFR inhibitors, including Del19/T790M/C797S and L858R/T790M/C797S The variant has good inhibitory activity while being highly selective for wild-type EGFR

At present, domestic companies developing fourth-generation EGFR inhibitors include Betta Pharmaceuticals, Zai Lab, Chia Tai Tianqing, Hongyun Bio, Qilu Pharmaceutical, and Jinan University

Among them, BPI-361175 developed by Betta Pharmaceuticals and TQB3804 developed by Chia Tai Tianqing have been approved for clinical use

BLU-701 has activity against EGFR activating mutations and C797S resistance mutations

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