Keeping "a valuable legacy on the tip of the tongue"

Original title: Inner Mongolia Dairy Biotechnology and Engineering Key Laboratory - Preservation of "Precious Heritage on the Tip of the Tongue Researchers went to the Tibetan herdsmen's families in Gannan Prairie to collect samples of traditional fermented milk Zhang Peace professor to guide the construction of lactic acid bacteria resourcebank However, behind the huge consumer market, few people know that for a long time, China's dairy enterprises in the production of fermented dairy products using bacteria, preparations and key technologies mainly rely on imports, seriously restricting the sustainable development of the industry.A research team driven by science and technology to promote the development of China's dairy industry is changing this situation through years of efforts and persistence - they have built Asia's largest resource bank of lactic acid bacteria; Sequencing, to fill the gaps in domestic research, relying on the self-created intestinal bacteria-based probiotic precision screening technology and evaluation system, screening out a number of probiotic strains with independent intellectual property rights, breaking the monopoly of foreign technology and products ...They are the dairy biotechnology innovation team from inner Mongolia Dairy Biotechnology and Engineering Key Laboratory (hereinafter referred to as the Laboratory) led by China's dairy expert Professor Zhang Peace. Aiming at "solving the major technical needs of the development of Lactobacillus and Fermented Milk Industry in China", the team has achieved a series of breakthrough results, realizing the industrialization of dairy fermentation agents, probiotic lactic acid bacteria preparations, animal micro-ecological preparations and silage fermentation agents, resulting in significant economic and social benefits.to rescue the disappearing speciesbuilt into Asia's largest lactic acid bacteria resource bankyogurt, lactic acid bacteria drinks, all contain the key ingredients - lactic acid bacteria. Lactic acid bacteria are a kind of bacteria that can produce a large amount of lactic acid by using fermentable carbohydrates, which are widely found in the human intestine and have the effect of regulating the intestinal bacterium and enhancing the body's immunity. With the deepening of research, intestinal microorganisms are regarded as an "important organ" of human beings and animals, and intestinal bacteria have become a hot research topic in the field of life science.resources are extremely precious agricultural heritage and natural resources, and are the material basis for the original innovation of agricultural science and technology and the development of modern species industry. Professor Zhang Peace is well aware that the future competition in the international breeding industry depends to a large extent on the excavation and effective use of species resources, who occupies a large number of species resources, a wide variety of species resources, who have the hope to make more contributions in the future economic development, and occupy the leading position.On the one hand, if the dairy industry wants to develop rapidly and get rid of foreign constraints, it objectively needs more and better probiotic germ resources, on the other hand, with the acceleration of urbanization, the traditional custom of making fermented milk is gradually diminishing, making many valuable lactic acid bacteria are gradually disappearing." purchase is not a long-term solution, should establish an independent intellectual property rights of lactic acid bacteria species. Since someone has to do it, let's do it! Professor Zhang Peace's words were heard loudly.the road is not good, not to the end;From 2001 to the present, Professor Zhang has led team members in a race against time to collect, identify and preserve lactic acid bacteria resources, overcome great difficulties, from Asia, Europe, Africa, South America and other countries to collect traditional fermented cow's milk, horse milk, camel milk, alpaca, yak milk, cheese and other products and porridge Natural fermented foods such as kimchi, rice wine, acid dough, olive juice and samples such as breast milk, baby droppings, honey, bark, etc. 3310 copies, from which to isolate and identify lactic acid bacteria 20201 strains, built Asia's largest lactic acid bacteria species resource bank, salvage preservation of the "precious heritage on the tip of the tongue."Relying on the self-created probiotic screening technology and evaluation system, the team has screened out 68 strains of probiotics with excellent characteristics, such as CheeseCillus Zhang, MilkYlobacteria V9, Plant Lactobacillus P-8, Swiss Lactobacillus H9, etc., breaking the technological monopoly of developed countries in this field.study of any strain of bacteria is not a one-off and requires many years of precipitation accumulation. Zhang, one of the representative probiotic species in the laboratory and named after Zhang, has many probiotic functions such as blood lipid reduction, immunomodulation, antioxidant, anti-intestinal pathogen growth, etc."Cheese Lactobacillus Zhang" isolated from the xilin Guole prairie natural fermentation of sour horse milk, in the laboratory for up to 18 years of systematic research, is China's first strain to complete the genome-wide sequencing of lactic acid bacteria, the first time in the international construction of cheese lactobacillus protein map, put forward a two-component strain system to improve gastrointestinal fluid tolerance theory, significantly enhance the scientific and technological innovation ability of China's probiotic lactic acid research.Clear Chinese gut microbiota structureovercome the problem of activity stability Now, more and more people are beginning to realize the positive effects of probiotics, but in the market, the quality of products containing probiotics and probiotics is uneven, consumers can not distinguish, and some foreign enterprises under the Chinese sequested for" brand sales products, which makes Zhang Peace feel sad." to develop probiotics, we must first understand what kind of structure of the Chinese intestinal bacteria, for accurate screening of probiotics to provide theoretical guidance. Zhang peace team took the lead in systematically studying the differences of 314 healthy people in 7 ethnic groups, such as Han, Mongolian and Tibetan, in 9 provinces of China, and clarified that Chinese groups of gut microorganisms are different from the intestinal microbial structure in the West, and that the community structure of the genus Koala is the dominant bacteria.On this basis, the team invented the precision screening technology of probiotic lactic acid bacteria based on the action of gut microorganisms, screened 68 strains of probiotic lactic acid bacteria suitable for the population of china from the genetic resource bank of lactic acid bacteria, and completed the probiotic function evaluation of strains from animal models, population trials and clinical studies, and solved the problem of backward precision screening technology of probiotic lactic acid bacteria and the scarcity of good strains.past, due to the instability of probiotic activity, many of the probiotics produced soon died, and now we have overcome this technical problem. The creation of micro-envelope membrane high-efficiency protection of probiotic lactic acid bacteria freeze-drying technology, so that the rate of live bacteria from 60% to more than 90%, the production of fermentation agents (preparations) live bacteria up to 500 billion - 1 trillion CFU /g, the overall product and technology reached the international advanced level. Zhang peace told reporters that at present, Mengniu, Zhongde Dairy, San MuGaoke, Bright Dairy, Wenshi Group, Modern Pastoral and other large dairy enterprises have adopted this technology and products, the transformation of related scientific and technological achievements, not only for enterprises to provide new technologies, enhance the core competitiveness of enterprises, while greatly increasing sales and profits, and achieved significant economic and social benefits.In order to make scientific and technological achievements better transformed and benefit more traditional dairy industries, based on the current situation and development trend of China's traditional dairy industry, the team also set up 23 demonstration points of modern dairy production technology in Inner Mongolia, Tibet, Xinjiang, Qinghai, Sichuan, Gansu and other regions, and innovated technology, standardized operating procedures, and formulated 12 food safety standards, which played a good role in increasing the income of local farmers and herdsmen.the vastness of the stars, the exploration is never-ending.As an important position of scientific and technological innovation, Inner Mongolia Dairy Biotechnology and Engineering Key Laboratory has team members from different backgrounds such as microbiology, genomics, medicine, bio-informationology and other groups to form a strong interdisciplinary academic lineup, converged into a powerful source of strength for laboratory development, they will practice "science and technology", strengthen the dairy innovation base, and make greater contributions to the high-quality development of the autonomous region.