Key protein synthesis mechanisms for Ebola virus revealed

Reporter 1 from the Chinese Academy of Agricultural Sciences Harbin Veterinary Research Institute was informed that the institute's basic immunization team Zheng Yonghui researcher and Dr. Wang Bin in the international first clarified the Ebola virus cystic glycosin synthesis mechanism, the relevant research results published online in the United States recently published in
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, the cystic glycoprotein on the surface of Ebola virus particles is the only protein that mediates viral infection of target cells and is therefore considered the preferred antigen for vaccine development and the ideal target for antiviral preparation development. But the mechanism of its maturity within the host cell is unclear, and the team has for the first time revealed and systematically explained how this key protein biosynthesizes in the host cell, so that it is expected to find a "drug switch" that does not allow it to be synthesized, and hopefully close the door to the virus infection.
ebola virus can cause severe Ebola haemorrhagic fever, there is currently no licensed vaccine for clinical use, and there are no specific antiviral drugs.
, after systematic research, researchers found that the endocystic network molecular companion calcium-linked protein and calcium-net protein involved in the maturation process of cystic glycoprotein. At the same time, it is found that GP2 sub-N-glycosylation of cystic glycoprotein play an important role in regulating protein expression and virus assembly. Further studies have found that N-glycosylation of GP2 sub-base affects the assembly and infection of viruses by participating in protein shearing, processing of protein sugar chains, formation of polypolymers, and protein folding.
According to Zheng Yonghui researchers, the virus must use the internal environment of the host cell to complete the maturation of its own protein and the assembly of virus particles, which involves a number of biological events of the precision regulatory process, any one of the links of abnormality or absence may lead to the virus can not be assembled and infected. This study sheds light on the detailed mechanism by which cells regulate protein function through cystic membrane glycosylation, which will provide a new theoretical basis for the development of anti-Ebola virus drugs. (Source: Science and Technology Daily Zhang Xiaopeng Li Liyun