Lactobacillus casei Zhang may reduce bacterial flora caused by antibiotics

1. Rats were randomly divided into 4 groups: control group, antibiotic treatment group, probiotics (Lactobacillus casei Zhang) after antibiotic treatment, and probiotics during and after antibiotic treatment (AB+Prob); 2. With other groups In comparison, the AB+Prob group had a significant increase in Parabacteroides gordonii (Pg), and a decrease in bacteria carrying antibiotic resistance genes; 3. In the intestinal metabolites of the two probiotic groups, acetic acid, propionic acid, butyric acid and Increased valeric acid content; 4. Potential probiotic Pg is significantly related to Lactobacillus casei Zhang, propionic acid, butyric acid and valeric acid; 5. Antibiotic treatment increases serum IL-1α (inflammation marker), and probiotic intervention makes it Lower . Editor-in-Chief Recommendations Zhang Wenyi's team from Inner Mongolia Agricultural University recently published a study in Computational and Structural Biotechnology Journal, showing that antibiotic treatment not only leads to the imbalance of the host intestinal flora, but also leads to inflammation and an increase in antibiotic resistance genes in the intestinal flora . Daily supplementation of Lactobacillus casei Zhang can alleviate these adverse side effects of antibiotic intervention and promote the restoration of intestinal flora homeostasis. These probiotic effects may be related to the beneficial effects mediated by Parabacteroides gordonii . Lactobacillus casei Zhang exerts probiotic effects to antibiotic -treated rats Lactobacillus casei Zhang has a probiotic effect in rats treated with antibiotics 10. 1016 / j. csbj. 2021. 10. 026 10-22, Article This article was the Abstract: Probiotics administration can facilitate the restoration of host gut microbiota/metabolome after antibiotic treatment. Yet, the mechanism behind such beneficial effects remains unclear. This study constructed a rat model of antibiotic-induced gut dysbiosis to monitor the effects and mechanism of probiotic (Lactobacillus casei Zhang) treatment in maintaining gut homeostasis and restoring the gut microbiota/metabolome. Forty rats were randomly divided into four groups (n = 10 per group): control receiving only saline (Ctrl), antibiotic (AB-Ctrl), antibiotic followed by probiotic (AB-Prob), and antibiotic plus probiotic followed by probiotic (AB + Prob). Rat fecal microbiota and sera were collected at four time points from pre-treatment to post-treatment. The probiotic-treated group (AB + Prob) had significantly more Parabacteroides (P. ) goldsteinii after one week of antibiotic and probiotic intervention but fewer antibiotic resistance genes (ARGs)-possessing bacteria (Clostridioides difficile and Burkholderiales bacterium). Consistently, metabolomics data revealed that both probiotic groups had more acetic acid, propionic acid, butyric acid, and valeric acid post treatment. Moreover, a potential probiotic species, P. goldsteinii, strongly correlated with L. casei, as well as propionic acid, butyric acid, and valeric acid. Furthermore, administering probiotic lowered the serum IL-1α level. In contrast , the antibiotic-recipients had a higher irreversible level of IL-1α, suggesting inflammation of the rats. Thus, antibiotic treatment not only led to host gut dysbiosis, but inflammatory responses and an increase in gut ARGs. Daily L. casei Zhang supplementation could alleviate the side effect of cefdinir intervention and facilitate the restoration of gut microbial homeostasis, and these probiotic effects might involve P. goldsteinii-mediated beneficial activities. First Authors: Guoqiang Yao,Chenxia Cao,Meng Zhang Correspondence Authors: Wenyi Zhang All Authors: Guoqiang Yao,Chenxia Cao,Meng Zhang,Lai-Yu Kwok,Heping Zhang,Wenyi Zhang   Disclaimer: This article only represents the author's personal views and has nothing to do with China Probiotics. com . The originality and the text and content stated in the article have not been verified by this site. This site does not make any guarantee or commitment to the authenticity, completeness, and timeliness of this article, all or part of the content, and the text. Please readers for reference only, and please Verify the relevant content yourself .   Copyright Notice 1. Some of the reprinted articles on this site are not original, and the copyright and liability belong to the original author . 2. All reprinted articles, links and pictures on this website are for the purpose of conveying more information, and clearly indicate the source and author. Media or individuals who do not want to be reprinted can contact us for infringement information that can provide sufficient evidence , Bio149 will be deleted within 12 hours after confirmation . 3. Users are welcome to post original articles to 86371366@qq. com, and publish them to the homepage after review. The copyright and liability belong to the sender .

1.
Rats were randomly divided into 4 groups: control group, antibiotic treatment group, probiotics (Lactobacillus casei Zhang) after antibiotic treatment, and probiotics during and after antibiotic treatment (AB+Prob);

2.
With other groups In comparison, the AB+Prob group had a significant increase in Parabacteroides gordonii (Pg), and a decrease in bacteria carrying antibiotic resistance genes;

3.
In the intestinal metabolites of the two probiotic groups, acetic acid, propionic acid, butyric acid and Increased valeric acid content;

4.
Potential probiotic Pg is significantly related to Lactobacillus casei Zhang, propionic acid, butyric acid and valeric acid;

5.
Antibiotic treatment increases serum IL-1α (inflammation marker), and probiotic intervention makes it Lower
.


Editor-in-Chief Recommendations

Zhang Wenyi's team from Inner Mongolia Agricultural University recently published a study in Computational and Structural Biotechnology Journal, showing that antibiotic treatment not only leads to the imbalance of the host intestinal flora, but also leads to inflammation and an increase in antibiotic resistance genes in the intestinal flora
.
Daily supplementation of Lactobacillus casei Zhang can alleviate these adverse side effects of antibiotic intervention and promote the restoration of intestinal flora homeostasis.
These probiotic effects may be related to the beneficial effects mediated by Parabacteroides gordonii
.


Lactobacillus casei Zhang exerts probiotic effects to antibiotic -treated rats

Lactobacillus casei Zhang has a probiotic effect in rats treated with antibiotics

10.
1016 / j.
csbj.
2021.
10.
026

10-22, Article This article was

the Abstract:

Probiotics administration can facilitate the restoration of host gut microbiota/metabolome after antibiotic treatment.
Yet, the mechanism behind such beneficial effects remains unclear.
This study constructed a rat model of antibiotic-induced gut dysbiosis to monitor the effects and mechanism of probiotic (Lactobacillus casei Zhang) treatment in maintaining gut homeostasis and restoring the gut microbiota/metabolome.
Forty rats were randomly divided into four groups (n = 10 per group): control receiving only saline (Ctrl), antibiotic (AB-Ctrl), antibiotic followed by probiotic (AB-Prob), and antibiotic plus probiotic followed by probiotic (AB + Prob).
Rat fecal microbiota and sera were collected at four time points from pre-treatment to post-treatment.
The probiotic-treated group (AB + Prob) had significantly more Parabacteroides (P.
) goldsteinii after one week of antibiotic and probiotic intervention but fewer antibiotic resistance genes (ARGs)-possessing bacteria (Clostridioides difficile and Burkholderiales bacterium).
Consistently, metabolomics data revealed that both probiotic groups had more acetic acid, propionic acid, butyric acid, and valeric acid post treatment.
Moreover, a potential probiotic species, P.
goldsteinii, strongly correlated with L.
casei, as well as propionic acid, butyric acid, and valeric acid.
Furthermore, administering probiotic lowered the serum IL-1α level.
In contrast , the antibiotic-recipients had a higher irreversible level of IL-1α, suggesting inflammation of the rats.
Thus, antibiotic treatment not only led to host gut dysbiosis, but inflammatory responses and an increase in gut ARGs.
Daily L.
casei Zhang supplementation could alleviate the side effect of cefdinir intervention and facilitate the restoration of gut microbial homeostasis, and these probiotic effects might involve P.
goldsteinii-mediated beneficial activities.


First Authors:

Guoqiang Yao,Chenxia Cao,Meng Zhang

Correspondence Authors:

Wenyi Zhang

All Authors:

Guoqiang Yao,Chenxia Cao,Meng Zhang,Lai-Yu Kwok,Heping Zhang,Wenyi Zhang

---

1.
Rats were randomly divided into 4 groups: control group, antibiotic treatment group, probiotics (Lactobacillus casei Zhang) after antibiotic treatment, and probiotics during and after antibiotic treatment (AB+Prob);

2.
With other groups In comparison, the AB+Prob group had a significant increase in Parabacteroides gordonii (Pg), and a decrease in bacteria carrying antibiotic resistance genes;

3.
In the intestinal metabolites of the two probiotic groups, acetic acid, propionic acid, butyric acid and Increased valeric acid content;

4.
Potential probiotic Pg is significantly related to Lactobacillus casei Zhang, propionic acid, butyric acid and valeric acid;

5.
Antibiotic treatment increases serum IL-1α (inflammation marker), and probiotic intervention makes it Lower
.


Editor-in-Chief Recommendations

Zhang Wenyi's team from Inner Mongolia Agricultural University recently published a study in Computational and Structural Biotechnology Journal, showing that antibiotic treatment not only leads to the imbalance of the host intestinal flora, but also leads to inflammation and an increase in antibiotic resistance genes in the intestinal flora
.
Daily supplementation of Lactobacillus casei Zhang can alleviate these adverse side effects of antibiotic intervention and promote the restoration of intestinal flora homeostasis.
These probiotic effects may be related to the beneficial effects mediated by Parabacteroides gordonii
.


Lactobacillus casei Zhang exerts probiotic effects to antibiotic -treated rats

Lactobacillus casei Zhang has a probiotic effect in rats treated with antibiotics

10.
1016 / j.
csbj.
2021.
10.
026

10-22, Article This article was

the Abstract:

Probiotics administration can facilitate the restoration of host gut microbiota/metabolome after antibiotic treatment.
Yet, the mechanism behind such beneficial effects remains unclear.
This study constructed a rat model of antibiotic-induced gut dysbiosis to monitor the effects and mechanism of probiotic (Lactobacillus casei Zhang) treatment in maintaining gut homeostasis and restoring the gut microbiota/metabolome.
Forty rats were randomly divided into four groups (n = 10 per group): control receiving only saline (Ctrl), antibiotic (AB-Ctrl), antibiotic followed by probiotic (AB-Prob), and antibiotic plus probiotic followed by probiotic (AB + Prob).
Rat fecal microbiota and sera were collected at four time points from pre-treatment to post-treatment.
The probiotic-treated group (AB + Prob) had significantly more Parabacteroides (P.
) goldsteinii after one week of antibiotic and probiotic intervention but fewer antibiotic resistance genes (ARGs)-possessing bacteria (Clostridioides difficile and Burkholderiales bacterium).
Consistently, metabolomics data revealed that both probiotic groups had more acetic acid, propionic acid, butyric acid, and valeric acid post treatment.
Moreover, a potential probiotic species, P.
goldsteinii, strongly correlated with L.
casei, as well as propionic acid, butyric acid, and valeric acid.
Furthermore, administering probiotic lowered the serum IL-1α level.
In contrast , the antibiotic-recipients had a higher irreversible level of IL-1α, suggesting inflammation of the rats.
Thus, antibiotic treatment not only led to host gut dysbiosis, but inflammatory responses and an increase in gut ARGs.
Daily L.
casei Zhang supplementation could alleviate the side effect of cefdinir intervention and facilitate the restoration of gut microbial homeostasis, and these probiotic effects might involve P.
goldsteinii-mediated beneficial activities.


First Authors:

Guoqiang Yao,Chenxia Cao,Meng Zhang

Correspondence Authors:

Wenyi Zhang

All Authors:

Guoqiang Yao,Chenxia Cao,Meng Zhang,Lai-Yu Kwok,Heping Zhang,Wenyi Zhang

---

1.
Rats were randomly divided into 4 groups: control group, antibiotic treatment group, probiotics (Lactobacillus casei Zhang) after antibiotic treatment, and probiotics during and after antibiotic treatment (AB+Prob);

2.
With other groups In comparison, the AB+Prob group had a significant increase in Parabacteroides gordonii (Pg), and a decrease in bacteria carrying antibiotic resistance genes;

3.
In the intestinal metabolites of the two probiotic groups, acetic acid, propionic acid, butyric acid and Increased valeric acid content;

4.
Potential probiotic Pg is significantly related to Lactobacillus casei Zhang, propionic acid, butyric acid and valeric acid;

5.
Antibiotic treatment increases serum IL-1α (inflammation marker), and probiotic intervention makes it Lower
.


Editor-in-Chief Recommendations

Zhang Wenyi's team from Inner Mongolia Agricultural University recently published a study in Computational and Structural Biotechnology Journal, showing that antibiotic treatment not only leads to the imbalance of the host intestinal flora, but also leads to inflammation and an increase in antibiotic resistance genes in the intestinal flora
.
Daily supplementation of Lactobacillus casei Zhang can alleviate these adverse side effects of antibiotic intervention and promote the restoration of intestinal flora homeostasis.
These probiotic effects may be related to the beneficial effects mediated by Parabacteroides gordonii
.


Lactobacillus casei Zhang exerts probiotic effects to antibiotic -treated rats

Lactobacillus casei Zhang has a probiotic effect in rats treated with antibiotics

10.
1016 / j.
csbj.
2021.
10.
026

10-22, Article This article was

the Abstract:

Probiotics administration can facilitate the restoration of host gut microbiota/metabolome after antibiotic treatment.
Yet, the mechanism behind such beneficial effects remains unclear.
This study constructed a rat model of antibiotic-induced gut dysbiosis to monitor the effects and mechanism of probiotic (Lactobacillus casei Zhang) treatment in maintaining gut homeostasis and restoring the gut microbiota/metabolome.
Forty rats were randomly divided into four groups (n = 10 per group): control receiving only saline (Ctrl), antibiotic (AB-Ctrl), antibiotic followed by probiotic (AB-Prob), and antibiotic plus probiotic followed by probiotic (AB + Prob).
Rat fecal microbiota and sera were collected at four time points from pre-treatment to post-treatment.
The probiotic-treated group (AB + Prob) had significantly more Parabacteroides (P.
) goldsteinii after one week of antibiotic and probiotic intervention but fewer antibiotic resistance genes (ARGs)-possessing bacteria (Clostridioides difficile and Burkholderiales bacterium).
Consistently, metabolomics data revealed that both probiotic groups had more acetic acid, propionic acid, butyric acid, and valeric acid post treatment.
Moreover, a potential probiotic species, P.
goldsteinii, strongly correlated with L.
casei, as well as propionic acid, butyric acid, and valeric acid.
Furthermore, administering probiotic lowered the serum IL-1α level.
In contrast , the antibiotic-recipients had a higher irreversible level of IL-1α, suggesting inflammation of the rats.
Thus, antibiotic treatment not only led to host gut dysbiosis, but inflammatory responses and an increase in gut ARGs.
Daily L.
casei Zhang supplementation could alleviate the side effect of cefdinir intervention and facilitate the restoration of gut microbial homeostasis, and these probiotic effects might involve P.
goldsteinii-mediated beneficial activities.


First Authors:

Guoqiang Yao,Chenxia Cao,Meng Zhang

Correspondence Authors:

Wenyi Zhang

All Authors:

Guoqiang Yao,Chenxia Cao,Meng Zhang,Lai-Yu Kwok,Heping Zhang,Wenyi Zhang

---