Lactobacillus plantarum concubine strain added to the fight against the new crown can significantly improve the effectiveness of the vaccine

The New Year is gradually approaching, but the wave of epidemics is still emerging one after another.
Whether the migrant workers can go home for the Chinese New Year smoothly also needs to be marked with a big question mark
.

The new coronavirus is not Sun Wukong, but has the ability to change seventy-two.
The appearance of the mutant strain Omicron in December disturbed the public's mood.
Now France has once again detected the mutant strain B.
1.
640.
2, which was named "IHU" "
.

So far, there have been so many mutated strains of the new coronavirus

Recently, the team of Academician Xu Jianguo of the Chinese Center for Disease Control and Prevention and Professor Xu Jianqing of the Institute of Biomedical Research of Fudan University carried out a collaborative research.
Finally, the research team found that a Lactobacillus plantarum strain GUANKE (LPG) can significantly enhance the effect of the new crown vaccine
.

The related research results were published online in Frontiers in Nutrition under the title "Boosting Vaccine-Elicited Respiratory Mucosal and Systemic COVID-19Immunity in Mice With the Oral Lactobacillus plantarum"

Research findings (source: Frontiers in Nutrition)

This study demonstrates that Lactobacillus plantarum GUANKE (LPG) can promote SARS-CoV-2-specific immune responses in vaccinated mice by enhancing interferon signaling and inhibiting apoptosis and inflammatory pathways
.

Administration of LPG to mice after the new crown vaccine can promote and maintain the production of new coronavirus neutralizing antibodies in their bodies

In this study, the researchers first determined experimentally whether LPG could enhance vaccine-induced effective immune responses in a COVID-19 vaccination model
.

The researchers found that oral administration of Lactobacillus plantarum GUANKE (LPG) to mice 24 weeks after inoculation with the new crown vaccine significantly enhanced and prolonged the new coronavirus-specific memory antibody response

Then, the researchers further carried out related research.
Immediately after inoculating the mice with the new crown vaccine, they were given oral Lactobacillus plantarum GUANKE (LPG) immediately, and a control group was set at the same time
.

After seven days, a significant increase in specific neutralizing antibody titers in the bronchoalveolar lavage (BAL) and serum of the mice was observed in the LPG group compared to the control group

In addition, the researchers found that LPG induced T-cell responses in mice
.

This shows that oral LPG can significantly enhance the humoral and cellular immune responses of mice to the new coronavirus after inoculation with the new crown vaccine

Oral administration of LPG after Covid-19 vaccine enhances humoral and cellular immune responses against SARS-CoV-2 in mice (Source: Frontiers in Nutrition)

So how does oral LPG enhance the immune response in mice after being vaccinated against the new crown vaccine? With this question in mind, the researchers performed transcriptome analysis of spleen cells, mediastinum, mesentery, small intestine, and colon tissue from mice in the LPG group
.

They found that oral administration of LPG promoted interferon responses in mice and inhibited apoptotic pathways and inflammatory responses

The above changes in the immune microenvironment further affect the adaptive immune response
.

By analyzing the RNA sequencing of T cells and B cell-related genes, the researchers found that genes related to B cell and T cell function were up-regulated in mice in the LPG group, indicating that oral LPG promoted the activation, proliferation and differentiation of B cells and T cells.

In conclusion, this study shows that oral administration of Lactobacillus plantarum GUANKE (LPG) after inoculation with the new crown vaccine can significantly enhance the effect of the vaccine against the virus.
The proliferation and activation of B cells in turn promotes the immune response
.

With the new crown epidemic still spreading around the world, the results of this research are undoubtedly encouraging.
It is hoped that human trials can be carried out as soon as possible, so that Lactobacillus plantarum GUANKE can be used as an adjuvant in combination with the new crown vaccine to increase the number of new crown vaccines epidemic prevention effect
.
I hope we can overcome the new crown virus as soon as possible and embrace each other in the sun
.