Lancet Infect Dis: Following surgical antibiotic prevention practice standards, rather than postoperative antibiotic prevention is the best way to prevent postoperative infections

To prevent surgical site infections, postoperative antibiotic preventive treatment usually lasts for 1 day or moreHowever, the study found that continued use of antibiotics after surgery may not have a significant advantage over immediate deactivation, but rather increasethe risk of antibiotic exposure in patientsIn 2016, WHO recommended that antibiotic prevention be discontinued after surgeryRecently, researchers examined the evidence of this viewThe study is a systematic overview and meta-analysis, collecting data from January 1, 1990 to July 24, 2018, involving randomized controlled trials (RCTs) for postoperative antibiotic preventionFor patients with any surgery with antibiotic prevention indications, the effect of continued use of antibiotics to prevent and discontinue antibiotic prevention on surgical site infection simply after surgery was comparedThe main result of the study was postoperative site infectionThe study included 52 RCTs, for a total of 19,273 participantsCompared with the immediate cessation of antibiotic prevention, the ratio of surgical site infections for continuous antibiotic prevention after surgery was 0.89, and the heterogeneity between studies was lowerThe study found that adherence to best practice standards for surgical antibiotic prevention significantly reduced the risk of postoperative infection: following best practice criteria reduced the risk of postoperative infection compared to termination of antibiotic prevention (RR.79), while continuous antibiotic treatment that did not meet the criteria had no significant effect on postoperative infection risk (1.04)Systematic review and meta-analysis show that there is no conclusive evidence that continued use of antibiotics after surgery is better than stopping antibiotic treatmentThere are no additional benefits to continuing antibiotic prevention after surgery when following best practice standards for surgical antibiotic prevention