Lancet Infection Dis: "Diamond Princess" cruise ship new crown pneumonia patient virus shedding and serum antibody reaction characteristics study

Infectious diseases are highly contagious in a closed environment such as cruise ships, and researchers recently examined the pattern of viral shedding and antibody response before and after symptoms appeared in patients diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the Cruise Ship in February 2020researchers recruited adult passengers from Hong Kong, aged 18, who were on board the Diamond Princess cruise ship, which was moored in Yokohama, Japan, in February 2020All subjects tested negative for nucleic acid serogas and serum G and Ig Ig for the internal nucleoproteinand and surface peak receptor binding protein (RBD) at baseline (when quarantined) and quarantine 4, 8 and 12 days during further isolation215 adult participants, 9 (4%) of whom tested positive for SARS-CoV-2 through RT-qPCR or serotonin and were hospitalizedOf the nine patients, 8 (89%) tested positive for nasopharyngeal swab RT-qPCR at the baseline testBy day 8, nine patients tested positive for RBD-IgGNasopharyngeal swabs RT-PCR and anti-RBD-IgG were positive for 8 cases (89%,) at the same time1 case of anti-RBD-IgG positive, nucleic acid test negative patients in high-resolution CT on the multi-topic peripheral hair glass changes,the typical performance of COVID-195 patients (56%) with a change in glass in high-resolution CT had higher levels of nucleoprotein IgG-OD values on days 8 and 12 and those with no-wool glass changes on the 8th and 12th daysDuring the 14-day isolation period, 6 (67%) asymptomatic patients never developed symptomspatients with COVID-19 develop asymptomatic lunginfectionaccompanied by viral shedding, while those with imaging signs of pneumonia tend to have an enhanced antibody responseIn patients with symptoms and asymptomatics, IgG or IgM positive confirmed COVID-19 infectionCase detection and contact tracking should be carried out in conjunction with RT-PCR and serology to facilitate early diagnosis , timely isolation and treatment