Lancet Sub-Journal & WCLC: A single chest CT screening can reduce lung cancer mortality by 1/3!

The lung cancer screening test began in the 1970s, based on chest X-rays and sputum analysis
.
However, there is no evidence of any mortality advantage

.

Screening was published in a landmark paper of the Early Lung Cancer Action Project (ELCAP) in 1999 on the potential of using LDCT for screening

The NLST report shows that through low-dose CT (LDCT) screening three times a year, lung cancer mortality has been significantly reduced by 20%
.
The subsequent Dutch-Belgian NELSON test showed a similar reduction

.

The NLST report shows that through low-dose CT (LDCT) screening three times a year, lung cancer mortality has been significantly reduced by 20%

From October 2011 to February 2013, the researchers randomly assigned 4055 participants to accept an LDCT screening invitation or not to accept screening (routine care)

.

Results 1987 participants in the intervention group and 1981 participants in the routine care group were followed for 7.
3 years (IQR 7.
1-7.
6)
.
Among them, 86 cases of cancer were diagnosed in the LDCT group and 75 cases in the control group

.

The risk of death from lung cancer in the diagnostic screening group was reduced by nearly 1/3 (RR=0.

Cumulative mortality of lung cancer

.

At the same time, in the screening group, the risk of lung cancer increased significantly as the number of nodules increased
.
In patients with 3 nodules, the risk of subsequent lung cancer was more than 6 times that of the 1 nodule group, and the risk of 4 nodules was 12 times that of the 1 nodule group

.

In the screening group, the risk of lung cancer increased significantly as the number of nodules increased

The UKLS single LDCT test shows that a single chest CT screening can reduce the death rate of lung cancer by 1/3! The study provides clear support for lung cancer screening in identified risk groups
.
The UKLS single LDCT test shows that a single chest CT screening can reduce the death rate of lung cancer by 1/3! The study provides clear support for lung cancer screening in identified risk groups
.

 

references:

Lung cancer mortality reduction by LDCT screening: UKLS randomised trial results and international meta-analysis.
https://doi.
org/10.
1016/j.
lanepe.
2021.
100179

Lung cancer mortality reduction by LDCT screening: UKLS randomised trial results and international meta-analysis.
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