Landmark! Domestic independent research and development of innovative drugs is expected to upgrade the "cocktail" therapy

On November 30, the Centers for Disease Control and Prevention released data: From January to October 2019, a total of 230 million people were tested nationwide, 131,000 cases of infection were detected in the new report, 127,000 new cases of antiviral treatment were added, and the proportion of people eligible for treatment in China receiving antiviral treatment was 86.6%, with a treatment success rate of 93.5%By the end of October 2019, 958,000 people had been reported alive nationwide, and although the overall outbreak continued to be at a low epidemic level, the number of infections was increasing year by yeareffective treatment of AIDS is antiretroviral therapy, commonly known as "cocktail therapy", and Rafmidin (3TC) is the core drug in "cocktail therapy"According to statistics, about 30 million people in the world are using 3TC, while China's use of anti-HIV treatment reached 100 percent3TC has been born for 30 years, the same varieties have not yet appeared in innovative drugs, so that its take a large dose, easy to produce resistance and many other birth defects have not been resolvedthe epoch-making, the emergence of domestic innovative drugsrecently, a domestic first with independent intellectual property rights, access to the country's "major new drug creation" science and technology major project support, is conditional early declaration of Phase II clinical data listed, will soon carry out Phase III clinical trials of anti-HIV oral drugs - Azfedin, caused industry concern, and is expected to end this field 30 years of no innovative drugs listed situationdose is small, oral convenienceAzvdin Phase I, Phase II clinical trial results show that Azvedin and 3TC treatment effect is comparable, and its dose is only one percent of 3TC, its dose advantage is significant3TC a tablet of about 300 mg, once a day, on the one hand, the patient cost is relatively high, while taking very little, and Azvdin take the dose of 3 mg, save a hundred times the dose but the effect is quite, fully reflectits its efficiencyexperts say the emergence of Azvedin is of epoch-making significance and is expected to replace 3TC as a new core drug in cocktail therapypatients resistant to ramifeddine, still effective
known as 3TC to produce resistance relatively quicklycompared to many years of use of lamifdin, produced a lot of resistance, in the clinical anti-resistance results show that Azvedin to ramifedin drug-resistant cell strains are still effective, which means that patients who develop resistance to ramifedin, taking Azvedin still has therapeutic effectlong-term, AIDS is expected to preventin vitro antiviral test results show that azved inhibition virus replication half of the effective dose is 0.03nM, and when the dose reached 100,000 nM, there are still no obvious toxic side effects on the cells, showing a high degree of selectivityin addition, the pharmacokinetic results in macaques and begg dogs showed that in the target cells of HIV, the concentration of effective drugs in peripheral blood mononucleosis cells was maintained at more than 1.35pM within 5 days after the drug, which is sufficient to effectively inhibit the replication of HIV and in vitro experiments to pre-add Azfding into the cell, four days later to join the virus, still 100% inhibited, experts said, the next step of the drug will be to develop oral long-acting, pre-exposure prevention direction This indicates that Azffordin is expected to become a long-lasting oral AIDS treatment drug, and may also play a key role in AIDS prevention services to China, pointing to the global market
Azfedin by Henan Real Biotech Co., Ltd research and development, for the original intention of the development of this drug Companies say the main purpose is to provide better and safer medicines to Chinese patients at present, China's use of "cocktail therapy" are all imported original research drugs or domestic generic drugs, and the existing antiviral drugs have adverse reactions, drug resistance and other problems Although AIDS patients can receive free antiviral drugs for life, but the long-term suffering of drug side effects, as well as the high cost of out-of-pocket drugs, many people will choose cross-border purchase, illegal channels, to some extent increasethed the risk of uncertainty about the lives of patients domestic enthusiasm for research and development of innovative drugs, entrepreneurs and scientists are not the only purpose of profitability, to promote them to take the first step, or deeply feel the gap between China's innovative drugs and the world's high level, is determined to explore new drugs for China to develop, to give Chinese patients a better and safer drug of course, enterprises are not taboo about the economic returns of Azvedin, Azvedin has broad spectrum in addition to antiviral drug indications, Azfdin also has lymphatic target; even AIDS, its positioning of the market is the operation of globalization, its double target, small dose, safety, long-term advantages in Europe and the United States, Africa and other regions will produce very obvious economic value.