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    Home > Medical News > Medical Science News > Latest research: Chimeric embryos can also successfully give birth to test-tube babies

    Latest research: Chimeric embryos can also successfully give birth to test-tube babies

    • Last Update: 2021-12-02
    • Source: Internet
    • Author: User
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    Latest research: Chimeric embryos can also successfully give birth to test-tube babies
    Latest research: Chimeric embryos can also successfully give birth to test-tube babies.
    Latest research: Chimeric embryos can also successfully give birth to test-tube babies.

     

    One limiting factor for the success of in vitro fertilization (IVF) is the number of viable embryos that can be implanted in the uterus
    .
    On November 19, a study published in the American Journal of Human Genetics showed that many embryos discarded or downgraded due to chromosomal abnormalities may lead to a successful pregnancy

    .
    These findings may have important implications for people undergoing IVF

    .

    "We believe that these clinical data will solve some of the major problems in preimplantation genetic testing, and further help many infertile patients make more informed fertility decisions
    .
    " Scientific expert Antonio Capalbo said, “This trial may promote changes in IVF clinical management and support relevant departments to update guidelines and recommendations

    .

    Researchers studied the prevalence and distribution of aneuploid cells (cells with unbalanced chromosomes) in blastocysts (embryo precursors) made in the laboratory
    .
    They particularly observed a condition called chimerism, where both normal and aneuploid cells are present in the embryo

    .
    Currently, less than 3% of chimeric embryos are used for IVF, and some clinics in the United States do not allow them to be transplanted

    .
    But the researchers found that in many of these chimeric blastocysts, the abnormal cells are confined to a small area that may not affect development

    .

    This time, the researchers conducted a double-blind trial.
    They selected patients who received IVF from 5 hospitals in Italy.
    Before implantation, the researchers conducted genetic tests on the embryos

    .
    In addition to euploid embryos, implanted embryos also include low chimerism (20% to 30% aneuploid cells) and medium chimerism (30% to 50% aneuploid cells)

    .
    The researchers said that the main result of the experiment was the live birth rate, and the secondary result was the abortion rate

    .

    "It is known that chimeric embryos may develop to term and produce healthy babies
    .
    However, many previous studies have been affected by selection biases, which tend to have a poor prognosis.
    These patients have previously used euploid embryos.
    The transfer failed

    .
    " He said, "In addition, the chimeric embryos were transferred to patients who only produced aneuploid embryos, again introducing a strong selection bias to people with poor prognosis

    .
    "

    The researchers say that the current study avoids this prejudice through non-selective trials
    .
    In this test, any embryo that meets the criteria is eligible for transplantation

    .
    In total, they found that in 484 euploid, 282 low chimera and 131 medium chimera embryos, the live birth rate and abortion rate were similar

    .
    Obstetrics and newborns have similar results

    .

    Capalbo said, “Our results show that the current mosaicism research does not provide any clinically useful information for IVF recipients
    .
    Therefore, it seems reasonable not to report relevant results after pre-implantation genetic testing.
    The treatment of variants of unknown significance in clinical genetic testing is similar

    .
    Even if these findings are reported, patients should be aware that the embryos are otherwise healthy and normal

    .
    "

    The researchers hope that this study will immediately affect clinical practice, prompt relevant departments to update guidelines and recommendations, and allow patients undergoing IVF to improve the decision-making process when evaluating chimeric embryo transfer
    .
    (Source: Feng Lifei, China Science News)

    Related paper information: https://doi.
    org/10.
    1016/j.
    ajhg.
    2021.
    11.
    002

    https://doi.
    org/10.
    1016/j.
    ajhg.
    2021.
    11.
    002
    https://doi.
    org/10.
    1016/j.
    ajhg.
    2021.
    11.
    002
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