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Literature interpretation: Flipping the enzyme ATP11B causes small cerebrovascular disease to occur without hypertension

 Last Update: 2022-09-14
 Source: Internet
 Author: User

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Small Vessel Disease (SVD) is often referred to as "small stroke" in the medical community, and although the symptoms are small, the harm is large, so it has gradually received attention

01 Evaluate the expression of the phospholipid flip enzyme ATP11B in a variety of brain cells

02 Construct Atp11b KO rats, and systematically knock out the Atp11b gene of rats

03 Assess the presence of dysfunction of endothelial cells in Atp11b KO rats

04 Imaging changes in the brain of Atp11b KO rats were observed by MRI

05 Analysis of behavioral characteristics changes in

Fig.

Figure 2 Atp11b KO rats exhibit an MR similar to SVD

Atp11b knockout mice

Mouse welfare, limited distribution medium ~

Strain Name:

C57BL/6J-Atp11b^em1Cya

Strain Number:

KOCMP-76295-Atp11b-B6J-VB

Product No.

S-KO-14829

Application Direction:

❖ Skeletal system

❖ Vision/Eyes; Limbs/tail

❖ Endothelial cell function; Cell localization, etc

Targeting Protocol:

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