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The 2019 Coronavirus (COVID-19) pandemic has become a related threat facing humanity worldwide
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Abnormal liver function tests (LFT) are more common in COVID-19 patients, but its clinical significance is controversial
Objective: To evaluate the prevalence, characteristics and clinical impact of abnormal LFTs in hospitalized non-critical COVID-19 patients
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Methods: A multi-center retrospective study method was used to collect data on 565 inpatients with COVID-19
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LFTs data were collected every 7±2 days during admission and during the hospitalization
The proportion of patients with abnormal LFTs transferred to the ICU The proportion of acute kidney injury requiring mechanical ventilation and mortality are higher than those of patients with no abnormal liver function
Table: Adjusted analysis of predictors of death or transfer to ICU during hospitalization; Legend: OR, odds ratio; CI, confidence interval; NEWS-2, national warning level 2; SOFA, sequential organ failure assessment; †, variable LOG transformation To be included in the analysis
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Figure Proportion of transfer to ICU or death
Figure Proportion of transfer to ICU or deathConclusion: Abnormal LFTs are common when COVID-19 patients are admitted to the hospital.
They are related to systemic inflammation and organ dysfunction, and are independent predictors of transfer to the intensive care unit or death
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They are related to systemic inflammation and organ dysfunction, and are independent predictors of transfer to the intensive care unit or death
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Original source
Piano S, Dalbeni A, Vettore E,et al, Abnormal liver function tests predict transfer to intensive care unit and death in COVID-19 .
Abnormal liver function tests predict transfer to intensive care unit and death in COVID-19 Leave a message here