Long-term use of PPIs-like gastric drugs is prone to heart disease, kidney disease and stomach cancer

As the saying goes, "ten stomachs and nine diseases." Heartburn, acid reflux, stomach ulcers..Many people have been plagued by these symptomsPPIs (proton pump inhibitors, various "rasplasts") are a commonly used class of gastric drugs that relieve symptoms by inhibiting the secretion of stomach acidSome patients with old stomach problems often buy over-the-counter drugs themselves without medical guidanceHowever, over-reliance on such gastric drugs also has health risksLong-term use of PPI may cause cardiovascular disease, chronic kidney disease and stomach cancer, according to a study led by the University of Washington School of Medicine, which is associated with a risk of premature deathThe findings were recently published in BMJimage source: BMJ's official websitethrough medical records from the U.SDepartment of Veterans Affairs database from July 2002 to June 2004, researchers screened 214,467 patients who took gastric drugs, 157,625 of whom were the latest doctors to prescribe PPIs and 56,842 who were newly prescribed another type of "H2 receptor antagonist" (various antitenasis)over a 10-year follow-up period, about 45 more deaths per 1,000 patients with PPI, equivalent to a 17 percent increase dying risk, compared to patients taking H2 antagonists"Given that millions of people regularly take PPI each year, this can lead to thousands of additional deaths," said study senior author DrZiyad Al-Aly, a nephrologist and clinical epidemiologist at the University of Washington School of Medicinefurther analysis of the causes of death found that taking PPI was mainly associated with deaths from cardiovascular disease, upper digestive tract cancer and chronic kidney diseaseSpecifically, the risk of additional deaths from cardiovascular disease, tumor and genitourinary diseases increased by 25%, 18% and 94% respectively in patients taking PPI, and the risk of additional death from upper digestive tract cancer increased by 41% and the risk of death from chronic kidney disease more than doubled in the latter two types of causes of deathThe underlying disease of the patient at the beginning of the study was not associated with the difference in risk of death in the two subsequent groupsnoted that more than half of the patients in the study who took PPI did not actually have a medical need, and in this group, PPI-related deaths were more common, with a 34%, 89% and 86% increased risk of dying from cardiovascular disease, stomach cancer and chronic kidney disease, respectively! In response, Dr Al-Aly said: "The most worrying concern for patients who do not need TO be treated with PPI but are taking medication is the harm of overdosingresearchers also found that the longer the duration of taking PPI, the higher the risk, even in low-dose medicationsat the beginning of the study, the use of PPI prescription drugs was not very widespread, and more than 80 percent of PPI users in the study had very low doses, equivalent to those in over-the-counter drugsThis means that even low-dose over-the-counter drugs pose risksThe team cautions that PPI prescription drugs should strictly follow indications, and that pharmacies need and explicitly remind patients when selling over-the-counter drugs that they usually take no more than 14 daysDrZiyad Al-Aly has led several studies on PPI and chronic kidney disease and death risk, and will continue to study the effects of PPI in the future for high-risk populationsIn addition, other studies have found that PPI is associated with health problems such as dementia, fractures, heart disease and pneumonia"It's not safe to take PPI drugs over the years, and now we can better understand the health effects of long-term PPI use," says DrZiyad Al-Alyin general, the research team recommends that, without clear medical indications, try to avoid taking PPI, do not advocate unauthorized use of drugs, self-long-term medicationOf course, PPI is still a classic and very effective gastric medicine, and patients who do need treatment should be administered at the lowest effective dose and the shortest course of treatmentReferencesEstimates of all cause mortality and cause pre-mortality with proton pumps peder US veterans: cohort studyBMJ, 10.1136/bmj.l1580Origind Jun 4, 2019, from https://original title BMJ 200,000 people study: Common stomach pills don't eat! Long-term use of disease, kidney disease and stomach cancer