Lpcat1 or a new target of tumor therapy

Recently, researchers found that lysophosphatidylcholinyltransferase (lpcat1) can change the phospholipid composition of tumor cell plasma membrane, promote the location of carcinogenic receptor on the cell surface, and then expand and change the growth factor signal to promote tumor growth, and proposed that lpcat1 can be a new target of tumor treatment The study was published in cell me tabolis With the progress of DNA sequencing technology, we have a further understanding of the molecular basis of tumor development Many studies have found that the content of lpcat1 in different tumor cells is significantly higher than that in normal cells Lpcat1 can associate gene changes in tumor cells with their metabolic changes, so as to promote tumor invasion and growth The researchers investigated the effect of lpcat1 on tumor growth in a variety of mouse tumor models The results showed that lpcat1 level decreased, tumor volume significantly reduced, and the survival time of mice significantly increased It was found that in the absence of lpcat1, the glycogen growth factor receptor dissociates from the cell membrane and blocks the growth factor signal transduction that causes tumor cell proliferation, thus inhibiting tumor cell growth and inducing tumor cell death The results show that lpcat1 may be a new target for the treatment of tumor, which can transform the plasma membrane structure of many tumor cells, and then affect the survival cycle and proliferation of tumor cells, providing a new direction for the research and development of new drugs (http://www.chemdrug.com/).