Lung Cancer: The impact of XPO1 mutation on the survival of metastatic non-small cell lung cancer (NSCLC)

Nuclear protein transport is the key to direct the transport of important proteins and RNA between the nucleus and cytoplasm

Nuclear protein transport is the key to direct the transport of important proteins and RNA between the nucleus and cytoplasm

A total of 18,218 NSCLC patients were studied, and 26 patients were found to be associated with XPO1 mutation (0.

A total of 18,218 NSCLC patients were studied, and 26 patients were found to be associated with XPO1 mutation (0.

Among XPO1 mutated tumors, TP53 is the most common co-mutated gene, accounting for 80% (20/25 cases)

Among the tumors amplified by XPO1, most tumors were positive for TP53, accounting for 95.

Commonly shared genes with genetic changes

17449 cases have complete clinical data, including 24 cases of XPO1 mutation

17449 cases have complete clinical data, including 24 cases of XPO1 mutation

Prognosis

In summary, this study shows that XPO1 mutations are associated with poor prognosis in NSCLC patients

In summary, this study shows that XPO1 mutations are associated with poor prognosis in NSCLC patients

Original source:

Nagasaka M, Asad MFB, Al Hallak MN, Uddin MH, et al.

Nagasaka M, Asad MFB, Al Hallak MN, Uddin MH, et al.
Impact of XPO1 mutations on survival outcomes in metastatic non-small cell lung cancer (NSCLC).
Lung Cancer.
2021 Aug 27;160:92-98.
doi: 10.
1016/j.
lungcan.
2021.
08.
010.
Epub ahead of print.
PMID: 34482103.


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