M6A mRNA modification regulates the latest developments in sperm production in mammals and its problems and challenges.

On November 2, the Tong Minghan Research Group of the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences was invited to present a review paper entitled m6A mRNA RegulateSE Des Mammalian Spermatogenesis at BBA-Gene Regulatory Mechanisms, which systematically summarized and discussed the latest developments in the development of m6A mRNA modification to regulate sperm production in mammals and their problems and challenges.
mammalian sperm production is a highly complex and coordinated process of cellular development.
process consists of three most basic biological events: silk split, subtractive division, and sperm formation.
in this process, gene expression in the transcription level, transcription level and translation level are strictly regulated, to ensure that sperm at different stages of functional specific gene expression.
therefore, the metabolism regulation of RNA is essential for the coordination of biological events in sperm production.
m6ARNA modification is a broad and conservative epigenetic modification, and studies have shown that m6ARNA modification is involved in the regulation of a variety of transcurrent levels and translation levels, including RNA variable shear, degradation, storage, translation, etc. In a recent special review of m6A-regulated sperm production published in BBA-Gene Regulatory Mechanisms, the
Tong Minghan Research Group analyzed in depth the complexity of gene expression regulation at various stages of mammalian sperm production, especially RNA metabolism regulation and its potential relationship with m6A RNA modification, and systematically summarized the latest developments in the properties and functions of m6ARNA modification in sperm production.
m6ARNA modification sits on dynamic changes in sperm production, which are directly related to stage-specific function.
functional studies of different m6A Writers, Erasers and Readers show that m6A plays a different role at different stages of sperm production.
on the basis of the current study, there are still many questions to be clarified, such as: is there any other unknown m6A Writers, Erasers, and Readers in sperm production? How do different m6A Writers, Erasers, and Readers choose different substrates at different stages of sperm production? Lin Zhen, a doctoral student in Tong Minghan Research Group, is the first author of the thesis, and the relevant work has been supported by the Chinese Academy of Sciences, the National Natural Science Foundation, the Ministry of Science and Technology, the Shanghai Science and Technology Commission, etc.
Source: Institute of Biochemistry and Cell Biology.