Macrophages contain inflammatory "brake" proteins

It is understood that high sugar and high fat food intake is easy to cause obesity, leading to metabolic diseases, such as diabetes, fatty liver, cardiovascular diseaseObesity can promote the progression of this disease by inducing chronic inflammation, but there are currently no drugs to effectively combat metabolic diseases against inflammatory targetsmacrophages play an important role in chronic inflammatory responses, and the dome body protein in adipose tissue is mainly expressed in macrophagesMice with a large phage dome protein deficiency were also more likely to develop atherosclerosis disorders such as weight gain, elevated blood sugar lipids and fatty liver, and mice who were fed a high-cholesterol diet were also more likely to develop atherosclerosisThe researchers also found that in both disease models, the inflammatory response of the body in mice with a loss of macrophages was significantly strongerFurther exploration by theteam confirmed that the main protein of dome can reduce the release of macrophages inflammatory factors, a fragment of the protein structure can play an anti-inflammatory roleMost convincingly, this small fragment of the dome body protein, expressed in macrophages, significantly reduces the inflammatory response of macrophagesChen Qi, the study is the first to find that the main protein can inhibit the inflammatory response of macrophages, playing a similar "brake" system in the bodyThis protein is usually unknown, but when the body has an inflammatory response, it will come forward to play a role in suppressing the inflammatory responseThis study provides a new target and basis for preventing and controlling a series of metabolic diseases such as obesity and coronary heart disease.