-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Main efficacy and function of pharmaceutical grade vanillin Vanillin XiangcaoquanVanillin C8H8O3 152.
15 [121-33-5] This product is 4-hydroxy-3-methoxy
.
Calculated by dry product, the content of C8H8O3 shall not be less than 99.
0%
.
【Properties】This product is white to slightly yellow needle or flake crystal or crystalline powder, with vanilla aroma
.
This product is easily soluble in methanol or ethanol, soluble in or hot water, slightly soluble in water
.
Melting point The melting point of this product (general rule 0612) is 81～84℃
.
[Identification] (1) In the chromatogram recorded under the related substances, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution
.
(2) The infrared absorption spectrum of this product should be consistent with that of the reference substance (general rule 0402)
.
【Check】Clarity and color of ethanol solution Take 1.
0g of this product, add 20ml of ethanol to dissolve, the solution should be clear and colorless (general rule 0901 and general rule 0902); No deeper (General Rule 0901 First Law)
.
Protect the material from light
.
Take an appropriate amount of this product and vanillin reference substance, dissolve and dilute with methanol to make a solution containing about 1mg per 1ml, as the test solution and the reference solution (new for immediate use)
.
According to the gas chromatography (general rule 0521) test, the capillary column with polydimethylsiloxane (or similar polarity) as the stationary liquid is used as the chromatographic column; the column temperature is 170 °C; the inlet temperature is 240 °C; the detector The temperature is 240℃
.
Precisely measure 1 μl of the reference solution, inject it into a gas chromatograph, record the chromatogram, and the theoretical plate number shall not be less than 5000 calculated according to the vanillin peak
.
Precisely measure 1 μl of the test solution, inject it into a gas chromatograph, and record the chromatogram to 3 times the retention time of the main peak
.
If there are impurity peaks in the chromatogram of the test solution, the resolution of each peak should meet the requirements
.
Calculated by the area normalization method, the sum of the peak areas of each impurity shall not be greater than 0.
5% of the total peak area
.
Loss on drying Take this product, use phosphorus pentoxide as a desiccant, and dry it under reduced pressure for 3 hours.
The weight loss should not exceed 1.
0% (General Rule 0831)
.
Take 1.
0g of this product for the residue on ignition and inspect it according to the law (General Rule 0841), and the remaining residue should not exceed 0.
05%
.
Heavy metals and residues left under residue on ignition shall be inspected in accordance with the law (the second method of General Rule 0821), and the heavy metals shall not exceed 10 parts per million
.
Arsenic salt: Take 2.
0g of this product, put it in a porcelain crucible, add 5ml of 15% magnesium nitrate solution, 0.
5g of magnesium oxide, mix well, soak for 4 hours, evaporate to dryness on a water bath, heat with low heat until carbonization is complete, at 550 ℃ Burn until the ashing is complete, let it cool, add an appropriate amount of water to wet the residue, add a few drops of phenolphthalein indicator solution, then slowly add 6mol/L hydrochloric acid solution dropwise until the red phenolphthalein fades, filter, put the filtrate in a 50ml volumetric flask, add a small amount of Wash the crucible with water several times, filter the washing liquid and put it into a measuring bottle, add water to dilute to the mark, shake well, and use it as the test solution
.
Take 16.
7ml of the test solution and check it according to the law (the first method of General Principle 0822), which should meet the regulations (0.
0003%)
.
【Determination of Content】Operate in the dark
.
Take about 0.
25g of this product, accurately weigh it, add 80ml of neutral ethanol to dissolve, add 3 drops of phenolphthalein indicator solution, and titrate with sodium hydroxide titration solution (0.
1mol/L).
.
Each 1ml of sodium hydroxide titration solution (0.
1mol/L) is equivalent to 15.
21mg of C8H8O3
.
【Category】Pharmaceutical excipients, flavors and fragrances
.
[Storage] Sealed and stored in a cool, dark and dry place
.
15 [121-33-5] This product is 4-hydroxy-3-methoxy
.
Calculated by dry product, the content of C8H8O3 shall not be less than 99.
0%
.
【Properties】This product is white to slightly yellow needle or flake crystal or crystalline powder, with vanilla aroma
.
This product is easily soluble in methanol or ethanol, soluble in or hot water, slightly soluble in water
.
Melting point The melting point of this product (general rule 0612) is 81～84℃
.
[Identification] (1) In the chromatogram recorded under the related substances, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution
.
(2) The infrared absorption spectrum of this product should be consistent with that of the reference substance (general rule 0402)
.
【Check】Clarity and color of ethanol solution Take 1.
0g of this product, add 20ml of ethanol to dissolve, the solution should be clear and colorless (general rule 0901 and general rule 0902); No deeper (General Rule 0901 First Law)
.
Protect the material from light
.
Take an appropriate amount of this product and vanillin reference substance, dissolve and dilute with methanol to make a solution containing about 1mg per 1ml, as the test solution and the reference solution (new for immediate use)
.
According to the gas chromatography (general rule 0521) test, the capillary column with polydimethylsiloxane (or similar polarity) as the stationary liquid is used as the chromatographic column; the column temperature is 170 °C; the inlet temperature is 240 °C; the detector The temperature is 240℃
.
Precisely measure 1 μl of the reference solution, inject it into a gas chromatograph, record the chromatogram, and the theoretical plate number shall not be less than 5000 calculated according to the vanillin peak
.
Precisely measure 1 μl of the test solution, inject it into a gas chromatograph, and record the chromatogram to 3 times the retention time of the main peak
.
If there are impurity peaks in the chromatogram of the test solution, the resolution of each peak should meet the requirements
.
Calculated by the area normalization method, the sum of the peak areas of each impurity shall not be greater than 0.
5% of the total peak area
.
Loss on drying Take this product, use phosphorus pentoxide as a desiccant, and dry it under reduced pressure for 3 hours.
The weight loss should not exceed 1.
0% (General Rule 0831)
.
Take 1.
0g of this product for the residue on ignition and inspect it according to the law (General Rule 0841), and the remaining residue should not exceed 0.
05%
.
Heavy metals and residues left under residue on ignition shall be inspected in accordance with the law (the second method of General Rule 0821), and the heavy metals shall not exceed 10 parts per million
.
Arsenic salt: Take 2.
0g of this product, put it in a porcelain crucible, add 5ml of 15% magnesium nitrate solution, 0.
5g of magnesium oxide, mix well, soak for 4 hours, evaporate to dryness on a water bath, heat with low heat until carbonization is complete, at 550 ℃ Burn until the ashing is complete, let it cool, add an appropriate amount of water to wet the residue, add a few drops of phenolphthalein indicator solution, then slowly add 6mol/L hydrochloric acid solution dropwise until the red phenolphthalein fades, filter, put the filtrate in a 50ml volumetric flask, add a small amount of Wash the crucible with water several times, filter the washing liquid and put it into a measuring bottle, add water to dilute to the mark, shake well, and use it as the test solution
.
Take 16.
7ml of the test solution and check it according to the law (the first method of General Principle 0822), which should meet the regulations (0.
0003%)
.
【Determination of Content】Operate in the dark
.
Take about 0.
25g of this product, accurately weigh it, add 80ml of neutral ethanol to dissolve, add 3 drops of phenolphthalein indicator solution, and titrate with sodium hydroxide titration solution (0.
1mol/L).
.
Each 1ml of sodium hydroxide titration solution (0.
1mol/L) is equivalent to 15.
21mg of C8H8O3
.
【Category】Pharmaceutical excipients, flavors and fragrances
.
[Storage] Sealed and stored in a cool, dark and dry place
.
