Main industrial separation technology of modern plant medicine

Resin separation technology Resin technology has been successfully used in industrial decolorization, environmental protection, drug analysis, antibiotic extraction and separation It has also been successfully applied to the separation and concentration of phytochemicals For example, for Ginkgo biloba leaves, the current resin separation technology can achieve the collection rate of Ginkgo biloba flavonoids of 90%; it can concentrate Ginkgo biloba flavonoids at one time, so that the content is more than 50%; it can also remove the vast majority (more than 99.5%) of ginkgo acid as a harmful component, so that it is less than 5ppm, and the loss of effective components is controlled below 3% Industrial extraction technology Including: ① organic solvent extraction technology; ② carbon dioxide supercritical fluid extraction technology, which is a technology developed in the 1990s, is to extract plant effective ingredients with liquid CO2 under high pressure (350-500bar) The product has high purity, high yield, and no pollution of extractant However, due to the high working pressure, the equipment requirements are high, and only the pilot test level is achieved at present; ③ new chlorofluorocarbon solvent extraction, such as the "klea" (HFC134 α, 1, 1, 1, 2 tetrafluorohexane) inert solvent recently invented by Zui in the UK, can be extracted at low pressure and room temperature, saving energy and avoiding thermal damage Ultrasonic extraction and separation technology: ultrasonic extraction tank of traditional Chinese medicine is mainly used in traditional Chinese medicine, food, agricultural products, health care products and other industries It is widely used in extraction of effective ingredients of traditional Chinese medicine and natural plants, suitable for various solvents (water or ethanol, petroleum ether, acetone and other organic solvents); it is a new construction, reconstruction and expansion of extraction workshop; development of new drugs and new products; Institute of Medical Sciences , University pharmaceutical enterprises and enterprises engaged in extraction use various methods to extract traditional Chinese medicine and natural products from plant and animal medicinal materials, experimental research and other aspects of the ideal extraction equipment; the whole machine is small in size, beautiful in appearance, easy to clean and maintain, in line with GMP certification requirements The ultrasonic extraction technology mainly reduces the force between the target extract and the sample matrix by the fast mechanical vibration wave generated by the piezoelectric transducer, so as to realize the solid-liquid extraction separation According to this principle and its working characteristics, the effective substances in traditional Chinese medicine can be treated The application of this technology plays an important role in the field of traditional Chinese medicine In the progress of human beings, it also brings the development of ultrasonic extraction technology of traditional Chinese medicine It also has a wider application for the treatment of traditional Chinese medicine Therefore, there are many effective methods for the treatment of traditional Chinese medicine in its development For the progress of society, the economic benefits it brings cannot be ignored Jining hengshuo ultrasonic machinery Co., Ltd submerged ultrasonic extraction technology for several years, and finally made some achievements in ultrasonic extraction Welcome friends from all over the country to come to discuss ultrasonic extraction technology, so that our ultrasonic extraction technology can achieve greater development! Table 1-2-1: examples of application of advanced technology in the production of plant extracts source: examples of application of process technology by the State Drug Administration ion exchange resin separation Separation of Ginkgo biloba leaf extract, soybean isoflavone continuous countercurrent extraction green tea extract and Trifolium pratense extract by synephrine and huperzine a macroporous adsorption resin High speed countercurrent partition chromatography tea EGCG (pilot production) adsorption chromatography paclitaxel, ginkgo lactone supercritical extraction Aromatic oil, natural vitamin E freeze-drying garlic extract hormone inclusion angelica extract (inclusion volatile oil) Enzymolysis of resveratrol Analysis and detection technology: the extract of traditional Chinese medicine requires quantitative analysis of the effective standard components and harmful substances, or comparison with the standard products, or identification by fingerprint Strict detection is required for raw materials, production process and finished products Taking natural sunshine company of the United States as an example, 150 tests are carried out from the beginning of raw materials to the factory of finished products Therefore, in the quality control of traditional Chinese medicine extracts, modern analytical instruments are essential Zui is widely used in HPLC At the same time, GC, HPCE, GC-MS, HPLC-MS, UV and atomic spectroscopic methods and instruments are often used According to statistics, more than 75% of Chinese herbal extracts were detected by HPLC, while only 10.9% of Chinese patent medicines in Chinese Pharmacopoeia were used Enterprises with low technology often do not have the ability of instrument analysis, and commercial enterprises rarely have these conditions