Making a solid breakthrough in the research of modern Chinese Medicine

Traditional Chinese medicine (TCM) is a unique medical culture and medical system in China It protects the Chinese nation from generation to generation and leads to prosperity Zhang Boli, academician of the Chinese Academy of engineering, President of the Chinese Academy of traditional Chinese medicine and President of Tianjin University of traditional Chinese medicine, who has the reputation of "general designer of modern Chinese medicine", once said affectionately that Chinese people are the happiest people in the world, because China has the culture of traditional Chinese medicine, and both Chinese and Western medicine are serving Chinese people So, in the modern society where Chinese medicine and Western medicine coexist, how to give full play to the advantages of traditional Chinese medicine to benefit more patients? Since passing the new drug review, Jingwanhong pharmaceutical industry has never stopped scientific research, but accelerated the pace of exploration and further research from multiple perspectives Jingwanhong pharmaceutical industry's insistence on scientific research has attracted the attention of TCM experts and pharmaceutical experts Many academicians have given guidance to the scientific research of Biqi Capsule Some of them have personally selected Biqi Capsule as the experimental drug for their own national key scientific research projects, and Biqi Capsule has proved its scientific, multi-functional, multi-target and safe efficacy Exactly, it is widely used, and is regarded as the "gold standard" of modern Chinese medicine innovation research Zhang Zhi, Zhou Zhe, ye Ying, all of the photos in this edition are from Beijing Wanhong pharmaceutical industry Academicians favor evidence-based medicine and evidence-based medicine The rapid rise of Biqi Capsule in the market of traditional Chinese medicine has attracted the attention of Wang Yongyan, a famous Chinese medicine expert, resource expert of traditional Chinese medicine and academician of Chinese Academy of engineering In 2005, a basic research project of the Ministry of science and technology of the people's Republic of China, which was promoted by Academician Wang Yongyan, "standards of traditional Chinese medicine and observation standards of clinical efficacy of related traditional Chinese medicine", used evidence-based medicine theory and experimental methods to promote the innovation of clinical efficacy evaluation methodology of traditional Chinese medicine through practical research on the clinical efficacy of standard Chinese medicine and related traditional Chinese medicine, so as to make traditional Chinese medicine go abroad The world has laid the foundation for summing up experience and establishing verification methods and standards In the process of selecting experimental drugs, Academician Wang Yongyan, after understanding, verifying and asking for opinions from many parties, finally ordered Biqi Capsule as the experimental drug of the subject, and carried out clinical reevaluation research After more than one year, 18 clinical units from 10 provinces and 10 provinces participated in the multicenter, large sample randomized controlled trial of 1120 cases of disease, and obtained the scientific evaluation of the efficacy, safety and long-term cardiovascular events of Biqi Capsule in the treatment of rheumatoid arthritis, cervical spondylosis, lumbar disc herniation and knee osteoarthritis This research result has strong evidence support for the safety and effectiveness of Biqi Capsule Traditional Chinese medicine has a long history The vast amount of traditional Chinese medicine prescriptions is an integral part of Chinese civilization With the development of history, the living environment, eating habits, physical fitness, genetic genes of human beings have changed significantly, and the disease spectrum has also changed accordingly So, are these traditional Chinese medicine prescriptions that have been used to protect human health in history still effective? At the same time, under the background that western medicine prevails and Western medicine research and development methods become international industry standards, can traditional Chinese medicine be recognized by modern medicine? Top level experimental design: three new discoveries of Biqi: Beijing Wanhong pharmaceutical industry's unremitting scientific research and development of Biqi Capsule has attracted the attention of many authoritative experts in the field of traditional Chinese medicine, including Zhang Boli, academician of Chinese Academy of engineering, President of Chinese Academy of traditional Chinese medicine and President of Tianjin University of traditional Chinese medicine, who has the reputation of "general designer of modern Chinese medicine" Experts once again for the characteristics of Biqi Capsule, the top-level experimental design A series of studies were carried out by means of cell molecular pharmacology and modern clinical pharmacology combined with high-throughput and high-content screening to explore the role of Biqi Capsule in the process of immunity and cartilage metabolism, and finally revealed the mechanism of Biqi Capsule's immune regulation and cartilage protection The development of traditional Chinese medicine from single drug to "prescription" is a leap forward The prescription of traditional Chinese medicine is not a simple combination of multiple herbs, but under the guidance of the theory of traditional Chinese medicine, it can be divided into monarch, minister, assistant and envoy, and can be divided into ascending, descending, floating and sinking herbs There is a long way to go for the research of Chinese herbal medicine, which is different from western medicine in emphasizing the effect of single active compound on a single target The components of Chinese herbal medicine, especially the components of Chinese herbal medicine, are extremely complex Each Chinese herbal medicine is a huge natural compound pool, in which the interaction will produce new components, which will produce multi-directional regulation on the body To achieve the purpose of mobilizing the internal factors of the body and regulating the balance of the body How to use modern science and technology to explain the regulatory effect of traditional Chinese medicine, especially the traditional compound preparation, reveal its mechanism of action, carry out modern research and development, and integrate traditional Chinese medicine into the modern science and technology system is a difficult problem for all medical workers Introducing evidence-based medicine to break through the bottleneck of traditional Chinese Medicine According to Academician Wang Yongyan, clinical efficacy is the best standard to test the success of modernization of traditional Chinese medicine The core connotation of modernization of traditional Chinese medicine is to verify the effective traditional Chinese medicine, especially the scientific method of compound Chinese medicine, and then promote the market according to the international general standard to share its good efficacy with the world Therefore, under his research and promotion, in 2005, the Ministry of science and technology of the people's Republic of China initiated and implemented the basic research project "the standard of traditional Chinese medicine and the clinical efficacy observation standard of related traditional Chinese medicine", applied evidence-based medicine knowledge, clinical epidemiology / DME, promoted the research of traditional Chinese medicine, sought a new way for the development of clinical medicine model of traditional Chinese medicine, and opened up a new development field of clinical medicine research of traditional Chinese medicine, To verify the efficacy and mechanism of traditional Chinese medicine In recent years, evidence-based medicine (EBM) is a new subject in the field of clinical medicine, which has become one of the hot spots in the current international medical research Since its founder Archie Cochrane, a British epidemiologist, first raised the issue of how to achieve both efficacy and effectiveness in health services more than 20 years ago, it has had a wide influence in the world Evidence based medicine refers to "evidence-based medicine" in terms of literal expression It emphasizes to obtain the basis from the systematic research, so that the research conclusions are based on convincing and sufficient evidence, so that the diagnosis and treatment means and methods are more effective and safe Systematic research includes basic medical scientific research, but more importantly, it refers to clinical research on diagnosis, treatment, rehabilitation and preventive measures The latest definition of evidence-based medicine is: "carefully, accurately and wisely apply the best research evidence available at present, at the same time, combine the professional skills and long-term clinical experience of clinicians, consider the values and wishes of patients, and perfectly combine the three together to develop a specific treatment plan" The research results of evidence-based medicine are the basis of health decision-making in many developed countries, which affect the medical practice, health decision-making, medical insurance (psychological insurance), medical education, medical research and new drug development in these countries Its ideas and methods can be used for reference for clinical treatment and clinical research of traditional Chinese medicine Traditional Chinese medicine (TCM) is a major feature of Chinese medical and health undertakings, which plays an important role in ensuring the health of Chinese people Over the years, China's traditional Chinese medicine industry has made great progress In the prevention and treatment of many major diseases, we have accumulated rich experience, developed many traditional Chinese medicine preparations with good clinical efficacy, and some have made breakthroughs The introduction of evidence-based medicine and systematic review in the field of traditional Chinese medicine and the research of traditional Chinese medicine will inject new vitality into the syndrome differentiation and treatment of traditional Chinese medicine, bring new situation to the scientific research of traditional Chinese medicine, and further promote the quality and level of clinical scientific research of traditional Chinese Medicine Determination of Biqi experimental drug by three standards The subject of "standards of traditional Chinese medicine and clinical efficacy observation standards of related traditional Chinese medicine" is one of the national key scientific research projects Its main purpose is to explore a demonstration mode of traditional Chinese medicine with a high level of evidence Therefore, the selection of experimental drugs for the subject is not only related to the success or failure of this subject, but also to the scientific research trend of the modernization of traditional Chinese medicine It must be strictly selected and carefully selected Careful Academician Wang Yongyan has worked out the selection criteria of experimental drugs after repeated deliberation: first, it must be a representative traditional Chinese medicine which has been listed and widely used; second, it should have the monarch, minister, assistant, envoy and complex compatibility of compound prescription; third, it has a certain scientific research basis and has proved to be effective According to the standard, the staff of the research group investigated from many aspects, such as legislation, formulation, efficacy, etc., extensively solicited opinions, selected at various levels, gradually narrowed the scope of candidates for traditional Chinese medicine, and Biqi Capsule stood out Academician Wang Yongyan pointed out that the occurrence of rheumatic arthralgia has both external and internal causes, the external cause is that the wind, cold and dampness enter into the human body, and the internal cause is that the human body's Qi and blood are insufficient, the reason is not dense, and the Defensive Qi is not solid (the resistance is reduced) External cause is the standard, internal cause is the basis Through the analysis of the prescriptions, Academician Wang Yongyan found that: the traditional Chinese medicine prescriptions for rheumatism are always based on the principles of expelling wind and dampness, dispersing cold and activating collaterals, and the prescriptions are also based on the traditional Chinese medicine for expelling wind and dampness, while Biqi Capsule is unique The prescriptions are evolved on the basis of the traditional Chinese medicine classic tonic prescriptions - Sijunzi Decoction, which is based on the principle of benefiting qi and nourishing collaterals According to the internal and external causes of rheumatic arthralgia and the pathogenesis, it can be said that it is a very unique Chinese medicine variety on the market After the academician's confirmation, Biqi Capsule was finally selected as the experimental drug for the basic research project of the Ministry of science and technology of the people's Republic of China, "standards of traditional Chinese medicine and clinical efficacy observation standards of related traditional Chinese medicine" The prescription of Biqi Capsule is composed of 10 kinds of drugs, which is very representative Its unique feature is that strychnine as the monarch drug has the effect of Tongluo, Zhitong, detumescence and resolving knots, and it has a definite effect on the treatment of rheumatism arthralgia It is not difficult to find out by using the theory of traditional Chinese medicine that semen Strychni (mixed powder) is the sovereign medicine, dangshen, Baizhu, Poria cocos and Danshen are the official medicine, dangshen, Baizhu, Poria cocos can strengthen the spleen and Qi, Danshen can nourish blood and blood, the four drugs are used to cut the pathogenesis, and can effectively protect the stomach and intestines With the help of Panax notoginseng, Ligusticum chuanxiong, Achyranthes bidentata and earthworm, it can promote blood circulation, remove stasis, dredge collaterals and relieve pain In addition, the composition principle of monarch, minister, assistant and emissary is fully embodied by the mixture of licorice and other drugs The compatibility of various drugs has strengthened the efficacy of Biqi Capsule in supplementing qi and nourishing blood, expelling wind and dehumidification, promoting blood circulation and relieving pain This medicine can expel wind, dispelling cold, removing dampness and dredging collaterals effectively After more than three years of careful research, the research team used high-throughput and high-content screening combined with cell molecular pharmacology, modern clinical pharmacology and other research methods to carry out a series of studies, to explore the role of Biqi Capsule in the immune and cartilage metabolism, and finally revealed the mechanism of Biqi Capsule in analgesia, anti-inflammatory, immune regulation and cartilage protection Immune regulation reveals the secrets of Jingtian In traditional Chinese medicine, it can cure the deficiency of Qi, blood, yin and Yang