In a new study, 9 people who received monoclonal antibodies were deliberately exposed to mosquitoes carrying malaria parasites
"This is a landmark study
Although the production cost of monoclonal antibodies is high, this work provides information for the development of a better vaccine than the currently widely used malaria vaccine
This preventive antibody binds to a small portion of circumsporozoite protein (CSP), which is located on the surface of these sporozoites
The research team isolated the CSP antibody from a person who received an experimental malaria vaccine for the first time
The research team led by immunologist Robert Seder of the National Center for Allergy and Infectious Disease Vaccine Research has used genetic engineering to produce a large number of modified antibodies that more than double the time that they can survive in the body before degradation
Seder said that ideally, a relatively low dose of antibody should be provided by subcutaneous injection, which is easier and cheaper than the relatively high dose of antibody provided by blood injection in this study
In addition, in 2019, three African countries began large-scale testing of an experimental malaria vaccine called RTS, S, which targets different parts of the CSP
Related paper information: https://doi.
https://doi.
org/10.
1056/NEJMoa2034031
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