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    Home > Biochemistry News > Microbiology News > Mapping DNA Target Sites of Chromatin Proteins In Vivo by Formaldehyde Crosslinking

    Mapping DNA Target Sites of Chromatin Proteins In Vivo by Formaldehyde Crosslinking

    • Last Update: 2021-01-31
    • Source: Internet
    • Author: User
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    The method described here is based on a technique developed to analyze the chromatin structure of the SV40 origin of replication, and also alterations in nucleosomal structures in the
    hsp70
    promoter of
    Drosophila
    after heat shock (
    1
    ,
    2
    ). It relies on the ability of formaldehyde to crosslink proteins and nucleic acids in living cells, from which chromatin can be isolated and protein-
    DNA
    interactions probed by immunoprecipitation using specific antibodies.
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