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Mass spectrometry system and Cong Yao's research group cooperate to reveal the structure and activation mechanism of mammalian PA28αβ-iCP immune proteasome

 Last Update: 2022-01-07
 Source: Internet
 Author: User

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(A) Immune proteasome PA28αβ-iCP and cryo-EM structure of iCP, PA28αβ can be bound to one end of iCP or both ends at the same time; (B) The relative spatial arrangement of PA28αβ and iCP; (C) PA28αβ-iCP The interaction interface between PA28αβ and iCP in the complex, where the C-terminal tail of PA28αβ inserted into the iCP loop is represented by the cyan density; (D) A schematic diagram of the molecular mechanism of PA28αβ binding and activating iCP

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