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    Home > Active Ingredient News > Drugs Articles > Matters needing attention when using Sihuan freeze-drying pharmaceutical freeze dryer

    Matters needing attention when using Sihuan freeze-drying pharmaceutical freeze dryer

    • Last Update: 2022-04-30
    • Source: Internet
    • Author: User
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    Sihuan freeze-drying pharmaceutical freeze-drying machine is a device for vacuum freeze-drying, called vacuum freeze-drying machine, which is mainly used for experimental research and development of vacuum freeze-dried materials
    .

    The working principle of the freeze-drying machine is: first pre-freeze and crystallize the materials containing moisture into a solid state, then perform primary drying and analytical drying in a vacuum environment, and directly sublimate the solid state into a gas to remove moisture to obtain materials with less water content
    .

     What should be paid attention to when using Sihuan freeze-drying pharmaceutical freeze dryer? The following matters should be noted: ①The flow pressure and temperature of the compressed air should be within the allowable range of the nameplate; ②The installation site should be ventilated, with less dust, and there should be enough space for heat dissipation and maintenance around the machine and cannot be installed outside the model to avoid rain and direct sunlight ; ③ The freeze dryer is generally allowed to be installed without foundation, but the ground must be leveled; ④ It should be as close as possible to the user point to avoid the pipeline being too long; ⑤ There should be no detectable corrosive gas in the surrounding environment, especially not with ammonia refrigeration equipment.
    Coexistence of one type; ⑥ The filtration precision of the pre-filter of the freeze dryer should be appropriate, too high precision is not necessary for the freeze dryer; The pressure difference causes the drainage to be blocked; ⑧ keep the drainage of the automatic drainer unobstructed at any time; ⑨ do not start the freeze dryer continuously; , it should be corrected according to the "correction factor" provided by the sample to avoid overload operation
    .

    The temperature uniformity and flatness of the four-ring freeze-drying pharmaceutical freeze dryer have a great impact on the uniformity of product quality.
    The better the temperature uniformity and flatness, the more uniform the quality of freeze-dried products.
    Good
    .

    Freeze dryer shelf temperature control has heater type and intermediate fluid type.
    The freeze dryer shelf with intermediate fluid control layer has good temperature uniformity and flatness.
    This freeze dryer plate layer is a hollow sandwich structure.
    The cooling and heating of the plate are realized through the circulation of the intermediate fluid in the fluid channel inside the plate, so the temperature of the plate is uniform
    .

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