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Nitric oxide (NO) has the potential to damage
DNA
directly, and also to react with O
2
to form the nitrosating species N
2
O
3
or to react with O
2−
to form the powerful oxidizing agent peroxynitrite (
see
Chapter 20 , this volume). The DNA-damaging activity of NO has been reviewed by Tannenbaum et al. (
1
).