Mediators Inflamm: The cascading of cogeneration factors and cytokines caused by the imbalance of Th1-Th2 is associated with elevated intracranial pressure in HIV-related cryptobacterial meningitis

Cytokines/cytokines in the serum play an important role in cryptobacterial meningitis, but it is not clear whether cytokines/cytokines in cerebrospinal fluid (CSF) lead to high intracranial pressure (HICP) of HIV-related cryptobacterial meningitis (HCM).
researchers tested CSF cytokines/chemical factors on 17 hiv-free patients, 26 HIV-infected patients without central nervous system infection, and 39 HIVM patients who were admitted to the hospital.
study Dismissal Oh has been published online at Mediators Inflamm.
results showed that levels of CSF Th1, Th2, and macrophage factors in HCM patients increased significantly compared to those who were not infected with HIV in the central nervous system.
CSF IL-6, GM-CSF, IL-8 and CSF fungal load were positively related.
Serum CD4 count, CSF Th1 cytokines (TNF-α, TNF-β, IL-12, IL-1 beta, IL-12, IL-1 alpha TNF-α, TNF-β, IL-12, IL-1 and IL-12) and Th2 cytokines (IL-4 and IL-10) promote HICP.
, the results of this study show that Th1, Th2, and macrophage sources of anti-inflammatory and anti-inflammatory cytokines are all contributing to the development of HCM.
specifically, the cascading of coercion factors and cytokines caused by the Th1-Th2 imbalance and the decrease in CD4 counting is an important promoter of HICP.
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