[Medicine heaven and earth] in February, 8 large-scale pharmaceutical enterprises were shut down; new procurement progress in three provinces, 28 drugs were suspended, 7 commonly used injections were expelled from one local procurement market; Liaoning promoted the reform of generic drugs into a new policy

Environmental protection investigation has been intensified and 8 enterprises have stopped production in February Recently, the fourth environmental protection supervision group of the central government sent letters and visits to Jiangxi Province to reflect the environmental pollution and inadequate rectification of Jiangxi Ruijin Wanqing Cement Co., Ltd., as well as the surface rectification and false rectification of Jiangxi Huiren Pharmaceutical Co., Ltd reported to Nanchang city Jiangxi Province immediately formed an investigation group to investigate and verify the environmental pollution, and dealt with the environmental pollution problems The rectification was ineffective 15 of the relevant responsible persons were seriously dealt with Nanchang county has taken measures to stop production and rectify Huiren Pharmaceutical Co., Ltd in Jiangxi Province, which requires that no construction can be started until the rectification is in place Xiaobian noted that not only Huiren pharmaceutical was punished, but also seven enterprises were shut down in recent two months due to environmental problems On May 3, 2018, Bozhou Environmental Protection Bureau received a report from municipal sewage treatment plant that the concentration of influent pollutants exceeded its treatment load, and it was suspected that high concentration industrial wastewater was discharged After investigation, law enforcement officers soon found that Guangzhou Baiyunshan Heji Huangpu traditional Chinese medicine (Bozhou) Co., Ltd in Qiaocheng economic development zone was suspected of being involved in the case On the morning of May 5, the law enforcement personnel of Bozhou Environmental Supervision Detachment issued the decision on production suspension and rectification to the company On May 12, 2018, Weiming Pharmaceutical Co., Ltd issued the announcement on the shutdown and relocation of wholly-owned subsidiaries The subsidiary Shandong Weiming Tianyuan Biotechnology Co., Ltd (hereinafter referred to as "Weiming Tianyuan") is located in the relocation area of the second phase of Zibo railway station south square reconstruction project, which was relocated within the time limit required by the government Therefore, the production of Weiming Tianyuan was stopped from May 8 On May 28, 2018, magic pharmaceutical Longli Branch received the decision of administrative penalty from Longli Environmental Protection Bureau and the decision of production suspension ordered by Longli Environmental Protection Bureau because the COD and BOD5 of the wastewater discharged into the municipal pipe network (finally into huangnishao sewage treatment plant) exceed the standard limit value specified in the integrated wastewater discharge standard The plant stopped production for remediation and was also ordered to stop production by Longli Environmental Protection Bureau Impose a fine of 200000 yuan On June 4, 2018, the media reported that "after a pharmaceutical enterprise in Zhuzhou County, Hunan Province secretly discharged excessive wastewater into Xiangjiang River, Zhuzhou County Party committee and county government attached great importance to it, ordered Zhuzhou songben pharmaceutical industry to stop production immediately, imposed administrative punishment on the illegal act of excessive wastewater discharge, and the relevant responsible person suspected of illegal by the enterprise has been transferred to the public security organ for treatment according to law In addition, the director of Zhuzhou Environmental Protection Bureau was removed On June 6, 2018, Yinchuan municipal Party committee and municipal government issued a notice: the complaints about Teri pharmaceutical, such as "although there are rectification measures, the treatment effect is not obvious, and the odor emission at night and holidays is more serious", are "basically true" Yongning County Government asked Teri pharmaceutical to stop the trial operation and continue to implement the shutdown Jiangsu Ruike Pharmaceutical Technology Co., Ltd (hereinafter referred to as "Jiangsu Ruike"), a subsidiary of Zhejiang Jiuzhou Pharmaceutical Co., Ltd (hereinafter referred to as "Jiuzhou pharmaceutical"), has stopped feeding materials in an all-round way since June 7, 2018 due to environmental protection problems, and submitted the shutdown plan and special rectification plan for hazardous waste disposal to the park management office on the same day, and the environmental protection deposit 1 has been deducted 0 yuan On June 20, 2018, the information released on the official website of Jiangsu Provincial People's government showed that Jiangsu AoXin Bioengineering Co., Ltd in Lianyungang Economic Development Zone was polluted by waste acid, waste alkali and peculiar smell On site inspection found that some of the company's projects were not approved for construction first and the environmental protection approval procedures were not fulfilled after the process change On June 13, the local Environmental Protection Bureau entrusted the municipal environmental monitoring center station to monitor the waste gas and waste water discharged by the enterprise After the monitoring report was issued, combined with the relevant test data, the local environmental protection bureau issued a decision letter on stopping production, remediation and administrative punishment to ANZ bio in strict accordance with the environmental protection laws and regulations 29 drugs, such as tetanus antitoxin, were removed from the list of commonly used low-cost drugs for limited price purchase On June 19, 2018, Liaoning provincial centralized purchasing network of drugs and medical consumables issued a notice, which pointed out that: 1) 28 drugs, such as tetanus antitoxin, will be transferred to the directory of Liaoning Province centralized purchasing drugs "temporarily not included in the list of drugs to be purchased through bidding"; 2) Ginkgo biloba capsule produced by Liaoning Yibang Pharmaceutical Co., Ltd will implement the relevant policies of low-cost drugs; 3) in the published drug directory The 20 drugs failing to provide effective basis will be postponed to July 31, 2018, and the overdue purchase will be stopped at 0:00 on August 1, 2018 (see the figure below for details) 2 Two enterprises are listed in the Sichuan procurement blacklist On June 21, 2018, Sichuan herbal medicine procurement center cancelled the qualification of fasudil hydrochloride injection (2ml: 300mg) produced by Tongliao Huabang Pharmaceutical Co., Ltd and hydroxymethylastan granules (0.2g) produced by wanquanwante Pharmaceutical (Xiamen) Co., Ltd to participate in the centralized procurement of the province, and listed the above two enterprises in the adverse records 3 Seven drugs were expelled from Jiangxi market On June 19, Jiangxi pharmaceutical purchasing service platform issued the notice on handling the non supply behavior of some "two envelope" winning products According to the research decision, for 7 "double envelope" winning products (see the figure below) that fail to fulfill the drug supply guarantee obligation, the qualification of winning bid and hanging net will be terminated from now on, and the qualification of bidding application for the next year will be cancelled 4 Reform local new policies on generic drugs On June 21, 2018, the general office of the people's Government of Liaoning Province issued the implementation opinions on reforming and improving the supply guarantee and use policy of generic drugs The document mainly proposes specific reform measures from three aspects: promoting the research and development of generic drugs, improving the quality and efficacy of generic drugs, and improving support policies Among them, the province has made clear regulations on newly approved generic drugs: if the generic name corresponding to generic drugs is not listed in the drug purchase catalogue, the provincial health and Family Planning Commission and relevant departments shall demonstrate on a quarterly basis from the date of approval for listing, and timely include it in the drug classified purchase list of Liaoning Province; for drugs subject to compulsory patent licensing by the state, it shall be unconditionally included in the drug centralized purchase list of Liaoning Province In addition, the national essential drugs and the drugs (mainly tumor targeted drugs) used by public hospitals in outpatient service that are under the management of high-value drugs in the medical insurance catalog are not included in the calculation of the proportion of drugs in public hospitals; medical and health institutions at all levels in Liaoning Province can temporarily increase the purchase and use of drugs that pass the quality and consistency evaluation of generic drugs before the end of 2018 5 The State Food and Drug Administration announced that 10 drugs were discontinued On June 22, 2018, the State Food and Drug Administration issued a circular on 10 batches of drugs that did not meet the requirements (No 46, 2018), including 9 pieces of traditional Chinese medicine (see the figure below) and 1 chemical preparation (metoprolol tartrate tablets) And the relevant drug supervision and administration departments have taken such control measures as sealing up and detaining the unqualified drugs, requiring the enterprises to suspend the sale and use of the products, recall the products, and carry out rectification.